Literature DB >> 2753153

Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen and specifically reacting with human anti-Sm auto-immune sera.

N G Sharpe1, D G Williams, D N Howarth, B Coles, D S Latchman.   

Abstract

A cDNA clone for the human SmB and B' auto-immune antigens has been isolated by antibody screening of a cDNA expression library. The cDNA clone hybridises with two distinct mRNAs, one of which is expressed in a tissue-specific manner. A fusion protein expressed from the cDNA clone was recognised by a number of sera from systemic lupus erythematosus (SLE) patients containing anti-Sm antibodies but not by sera reactive with other auto-immune antigens. The potential use of this clone in a diagnostic assay for SLE and in elucidating the processes regulating the expression of SmB and B' is discussed.

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Year:  1989        PMID： 2753153     DOI： 10.1016/0014-5793(89)80801-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

Review 1.  B-cell epitopes of Sm autoantigens.

Authors:  L A Rokeach; S O Hoch
Journal:  Mol Biol Rep       Date:  1992-06       Impact factor: 2.316

Review 2.  Antinuclear antibody determination methods.

Authors:  D G Williams; P J Charles; M Field; S M Chua; R N Maini
Journal:  Clin Rheumatol       Date:  1990-03       Impact factor: 2.980

3.  Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation.

Authors:  N G Sharpe; D G Williams; D S Latchman
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

4.  Expression of the tissue specific RNA splicing protein SmN in HeLa cells.

Authors:  N G Sharpe; W Wall; D S Latchman
Journal:  Nucleic Acids Res       Date:  1990-06-11       Impact factor: 16.971

Review 5.  Mice lacking Snrpn expression show normal regulation of neuronal alternative splicing events.

Authors:  J D Huntriss; J A Barr; D A Horn; D G Williams; D S Latchman
Journal:  Mol Biol Rep       Date:  1994-07       Impact factor: 2.316

6.  cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.

Authors:  T Lehmeier; V Raker; H Hermann; R Lührmann
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-06       Impact factor: 11.205
  6 in total

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