| Literature DB >> 27530607 |
Yan Liu1, Shuai Liu1, Dan Luo2,3, Zhenjie Xue2, Xinan Yang4, Lin Gu4, Yanheng Zhou5, Tie Wang6.
Abstract
A hierarchical, intrafibrillarly mineralized collagen (HIMC) is achieved through a selective mineralization progress in the collagenous gap regions mediated by poly(acrylic acid) with appropriate molecular weight. The associated topographical features directly correlate with nanomechanical heterogeneities of the HIMC to accommodate a broad range of external loads. Moreover, this hierarchically staggered nanostructure provides an optimized microenvironment to improve bone regeneration by instructing host cells.Entities:
Keywords: bone regeneration; intrafibrillar mineralization; staggered nanostructures; stem cells
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Year: 2016 PMID: 27530607 DOI: 10.1002/adma.201602628
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849