Satish Khadilkar1, Bhagyadhan Patel1, Khushnuma A Mansukhani2, Sunila Jaggi3. 1. Department of Neurology, Grant Medical College and Sir J.J. Group of Hospitals, Mumbai, India. 2. Department of Neurophysiology, Bombay Hospital, Mumbai, India. 3. Department of Radiology, Bombay Hospital and Medical Research Centre, Mumbai, India.
Abstract
INTRODUCTION: Immune-mediated demyelinating radiculopathies restricted to proximal sensory or motor roots are uncommon. METHODS: We report the clinical, electrophysiological, biochemical, and radiological features in 2 patients with chronic immune sensorimotor polyradiculopathy (CISMP). RESULTS: The patients presented with sensory ataxia, weakness of the lower limbs, and areflexia. Electrophysiological studies revealed involvement of proximal sensorimotor roots, as evidenced by changes in somatosensory evoked potentials, F-waves, and H-reflexes. In contrast, the distal nerve segments were normal. Magnetic resonance neurography findings of thickened and enhanced roots supported the electrophysiological findings. The response to immunosuppressive therapy was favorable in both patients. CONCLUSION: The findings from these 2 patients further expand the knowledge spectrum of immune polyradiculopathies. Muscle Nerve 55:135-137, 2017.
INTRODUCTION: Immune-mediated demyelinating radiculopathies restricted to proximal sensory or motor roots are uncommon. METHODS: We report the clinical, electrophysiological, biochemical, and radiological features in 2 patients with chronic immune sensorimotor polyradiculopathy (CISMP). RESULTS: The patients presented with sensory ataxia, weakness of the lower limbs, and areflexia. Electrophysiological studies revealed involvement of proximal sensorimotor roots, as evidenced by changes in somatosensory evoked potentials, F-waves, and H-reflexes. In contrast, the distal nerve segments were normal. Magnetic resonance neurography findings of thickened and enhanced roots supported the electrophysiological findings. The response to immunosuppressive therapy was favorable in both patients. CONCLUSION: The findings from these 2 patients further expand the knowledge spectrum of immune polyradiculopathies. Muscle Nerve 55:135-137, 2017.
Authors: Shahar Shelly; Kamal Shouman; Pritikanta Paul; JaNean Engelstad; Kimberly K Amrami; Robert J Spinner; Divyanshu Dubey; Rocio Vazquez Do Campo; Peter J Dyck; Christopher J Klein; P James B Dyck Journal: Neurology Date: 2021-03-02 Impact factor: 9.910