L Mamluk1, M G O'Doherty1, P Orfanos2, G Saitakis2, J V Woodside1, L M Liao3, R Sinha3, P Boffetta4,5, A Trichopoulou2,5, F Kee1. 1. UKCRC Centre of Excellence for Public Health for Northern Ireland, Queens University Belfast, Belfast, UK. 2. Department of Hygiene, University of Athens, Epidemiology and Medical Statistics, Athens, Greece. 3. Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Rockville, MD, USA. 4. The Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York, NY, USA. 5. Hellenic Health Foundation, Athens, Greece.
Abstract
BACKGROUND/ OBJECTIVES: There is limited information to support definitive recommendations concerning the role of diet in the development of type 2 Diabetes mellitus (T2DM). The results of the latest meta-analyses suggest that an increased consumption of green leafy vegetables may reduce the incidence of diabetes, with either no association or weak associations demonstrated for total fruit and vegetable intake. Few studies have, however, focused on older subjects. SUBJECTS/ METHODS: The relationship between T2DM and fruit and vegetable intake was investigated using data from the NIH-AARP study and the EPIC Elderly study. All participants below the age of 50 and/or with a history of cancer, diabetes or coronary heart disease were excluded from the analysis. Multivariate logistic regression analysis was used to calculate the odds ratio of T2DM comparing the highest with the lowest estimated portions of fruit, vegetable, green leafy vegetables and cabbage intake. RESULTS: Comparing people with the highest and lowest estimated portions of fruit, vegetable or green leafy vegetable intake indicated no association with the risk of T2DM. However, although the pooled OR across all studies showed no effect overall, there was significant heterogeneity across cohorts and independent results from the NIH-AARP study showed that fruit and green leafy vegetable intake was associated with a reduced risk of T2DM OR 0.95 (95% CI 0.91,0.99) and OR 0.87 (95% CI 0.87,0.90) respectively. CONCLUSIONS: Fruit and vegetable intake was not shown to be related to incident T2DM in older subjects. Summary analysis also found no associations between green leafy vegetable and cabbage intake and the onset of T2DM. Future dietary pattern studies may shed light on the origin of the heterogeneity across populations.
BACKGROUND/ OBJECTIVES: There is limited information to support definitive recommendations concerning the role of diet in the development of type 2 Diabetes mellitus (T2DM). The results of the latest meta-analyses suggest that an increased consumption of green leafy vegetables may reduce the incidence of diabetes, with either no association or weak associations demonstrated for total fruit and vegetable intake. Few studies have, however, focused on older subjects. SUBJECTS/ METHODS: The relationship between T2DM and fruit and vegetable intake was investigated using data from the NIH-AARP study and the EPIC Elderly study. All participants below the age of 50 and/or with a history of cancer, diabetes or coronary heart disease were excluded from the analysis. Multivariate logistic regression analysis was used to calculate the odds ratio of T2DM comparing the highest with the lowest estimated portions of fruit, vegetable, green leafy vegetables and cabbage intake. RESULTS: Comparing people with the highest and lowest estimated portions of fruit, vegetable or green leafy vegetable intake indicated no association with the risk of T2DM. However, although the pooled OR across all studies showed no effect overall, there was significant heterogeneity across cohorts and independent results from the NIH-AARP study showed that fruit and green leafy vegetable intake was associated with a reduced risk of T2DM OR 0.95 (95% CI 0.91,0.99) and OR 0.87 (95% CI 0.87,0.90) respectively. CONCLUSIONS: Fruit and vegetable intake was not shown to be related to incident T2DM in older subjects. Summary analysis also found no associations between green leafy vegetable and cabbage intake and the onset of T2DM. Future dietary pattern studies may shed light on the origin of the heterogeneity across populations.
Authors: Nicole Jankovic; Anouk Geelen; Martinette T Streppel; Lisette C P G M de Groot; Philippos Orfanos; Edith H van den Hooven; Hynek Pikhart; Paolo Boffetta; Antonia Trichopoulou; Martin Bobak; H B Bueno-de-Mesquita; Frank Kee; Oscar H Franco; Yikyung Park; Göran Hallmans; Anne Tjønneland; Anne M May; Andrzej Pajak; Sofia Malyutina; Růžena Kubinova; Pilar Amiano; Ellen Kampman; Edith J Feskens Journal: Am J Epidemiol Date: 2014-10-15 Impact factor: 4.897
Authors: Daniel B Ibsen; Kim Overvad; Anne Sofie D Laursen; Jytte Halkjær; Anne Tjønneland; Tuomas O Kilpeläinen; Erik T Parner; Marianne U Jakobsen Journal: Eur J Nutr Date: 2021-03-04 Impact factor: 5.614
Authors: Ju-Sheng Zheng; Stephen J Sharp; Fumiaki Imamura; Rajiv Chowdhury; Thomas E Gundersen; Marinka Steur; Ivonne Sluijs; Yvonne T van der Schouw; Antonio Agudo; Dagfinn Aune; Aurelio Barricarte; Heiner Boeing; María-Dolores Chirlaque; Miren Dorronsoro; Heinz Freisling; Douae El-Fatouhi; Paul W Franks; Guy Fagherazzi; Sara Grioni; Marc J Gunter; Cecilie Kyrø; Verena Katzke; Tilman Kühn; Kay-Tee Khaw; Nasser Laouali; Giovanna Masala; Peter M Nilsson; Kim Overvad; Salvatore Panico; Keren Papier; J Ramón Quirós; Olov Rolandsson; Daniel Redondo-Sánchez; Fulvio Ricceri; Matthias B Schulze; Annemieke M W Spijkerman; Anne Tjønneland; Tammy Y N Tong; Rosario Tumino; Elisabete Weiderpass; John Danesh; Adam S Butterworth; Elio Riboli; Nita G Forouhi; Nicholas J Wareham Journal: BMJ Date: 2020-07-08