| Literature DB >> 27530408 |
Emilia Saint Martin1, Emilce E Schneeberger1, Federico M Aranda2, Silvia Wingeyer Peres2, María Del Carmen Valerio1, Maria de Los Angeles Correa1, Fernando Dal Pra1, Liliana Martinez3, Graciela Remondino3, Gabriela de Larrañaga2, Gustavo Citera4.
Abstract
The aim of this study was to analyze the influence of nucleotide transition (G/A) in position -2518 of the MCP-1 gene related to the susceptibility of developing RA. Two hundred twenty-three consecutive RA patients according to 2010 ACR/EULAR criteria were included; 120 healthy subjects were used as controls. MCP-1 -2518 A/G polymorphism (AG + GG) was present in 162 (72.6 %) RA patients and in 63 (52.5 %) healthy subjects [OR 2.44 (IC95% 1.53-3.88, p = 0.0002)]; associations for heterozygotes and homozygotes were OR 1.92 (IC95% 1.19-3.15, p = 0.001) and OR 5.19 (IC95% 2.34-11.51, p = 0.001), respectively. In Argentine patients, MCP-1 gene polymorphism confers susceptibility for developing RA.Entities:
Keywords: Genetics; Methodology, rheumatoid arthritis (RA); Rheumatic diseases, immunology; Specialty fields, cytokines and inflammatory mediators; Tissues or models
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Year: 2016 PMID： 27530408 DOI： 10.1007/s10067-016-3380-0
Source DB: PubMed Journal: Clin Rheumatol ISSN： 0770-3198 Impact factor: 2.980