Literature DB >> 27530357

Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines.

Yonghui Liu1, Wenpeng Zhang, Qianqian He, Fan Yu, Tianbang Song, Tingting Liu, Zhenqing Zhang, Jun Zhou, Peng George Wang, Wei Zhao.   

Abstract

We have designed and synthesized MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential self-adjuvanting cancer vaccines using a linear solid phase peptide synthesis strategy. These vaccine candidates have elicited T cell dependent immune response and the induced antibodies showed intense specific binding affinity to human MCF-7 cells.

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Year:  2016        PMID： 27530357     DOI： 10.1039/c6cc04623a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Design of a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancer immunotherapy.

Authors:  Mingjing Li; Zhaoyu Wang; Bocheng Yan; Xiaona Yin; Yue Zhao; Fan Yu; Meng Meng; Yonghui Liu; Wei Zhao
Journal:  Medchemcomm       Date:  2019-07-12       Impact factor: 3.597

2.  Synthesis and Immunological Evaluation of a Multicomponent Cancer Vaccine Candidate Containing a Long MUC1 Glycopeptide.

Authors:  Nitin T Supekar; Vani Lakshminarayanan; Chantelle J Capicciotti; Anju Sirohiwal; Cathy S Madsen; Margreet A Wolfert; Peter A Cohen; Sandra J Gendler; Geert-Jan Boons
Journal:  Chembiochem       Date:  2017-11-30       Impact factor: 3.164

3.  Design, Synthesis, and Preliminary Immunological Studies of MUC1-Based Antitumor Vaccines Adjuvanted with R- and S-FSL-1.

Authors:  Yonghui Liu; Bocheng Yan; Zhaoyu Wang; Haomiao Zhu; Xiaona Yin; Kun Wang; Menglei Wang; Wei Zhao
Journal:  ACS Med Chem Lett       Date:  2020-06-22       Impact factor: 4.345

4.  The Adjuvant of α-Galactosylceramide Presented by Gold Nanoparticles Enhances Antitumor Immune Responses of MUC1 Antigen-Based Tumor Vaccines.

Authors:  Yonghui Liu; Zhaoyu Wang; Fan Yu; Mingjing Li; Haomiao Zhu; Kun Wang; Meng Meng; Wei Zhao
Journal:  Int J Nanomedicine       Date:  2021-01-14

5.  Multifunctional Protein Conjugates with Built-in Adjuvant (Adjuvant-Protein-Antigen) as Cancer Vaccines Boost Potent Immune Responses.

Authors:  Jing-Jing Du; Chang-Wei Wang; Wen-Bo Xu; Lian Zhang; Yuan-Kai Tang; Shi-Hao Zhou; Xiao-Fei Gao; Guang-Fu Yang; Jun Guo
Journal:  iScience       Date:  2020-02-24
  5 in total

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