Gunn Ammitzbøll1, Karen Søgaard2, Randi V Karlsen3, Anne Tjønneland4, Christoffer Johansen5, Kirsten Frederiksen3, Pernille Bidstrup3. 1. Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark; Institute of Sports Medicine and Biomechanics, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. Electronic address: gunnam@cancer.dk. 2. Institute of Sports Medicine and Biomechanics, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. 3. Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark. 4. Diet, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark. 5. Survivorship Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark; The Finsen Centre, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Abstract
PURPOSE: Knowledge about lifestyle factors possibly influencing survival after breast cancer (BC) is paramount. We examined associations between two types of postdiagnosis physical activity (PA) and overall survival after BC. PATIENTS AND METHODS: We used prospective data on 959 BC survivors from the Diet, Cancer, and Health cohort, all enrolled before diagnosis. Self-reported PA was measured as time per activity, and estimated metabolic equivalent task (MET)-hours per week were summed for each activity. We constructed measures for household, exercise, and total PA. The association between postdiagnosis PA and all-cause mortality was estimated as hazard ratio (HRs) based on Cox proportional hazards model, with time since diagnosis as the underlying time scale. Prediagnosis PA, body mass index (BMI), and receptor status were examined as potential effect modifiers. RESULTS: We identified 144 deaths from all causes during the study period. In adjusted analyses, exercise PA above eight MET h/week compared to lower levels of activity was significantly associated with improved overall survival (HR, 0.68; confidence interval [CI]: 0.47-0.99). When comparing participation in exercise to non-participation, we found a 44% risk reduction in overall survival (HR, 0.56; CI: 0.33-0.95). Neither between household nor total PA and overall survival did, we find significant associations. Prediagnosis PA, BMI, and receptor status did not modify the effect significantly. CONCLUSION: Exercise PA corresponding to 2.5 h or more of brisk weekly walking after BC diagnosis may reduce mortality by up to 32% compared to low-level exercise. Participation in exercise PA may reduce mortality by 44% compared to non-participation.
PURPOSE: Knowledge about lifestyle factors possibly influencing survival after breast cancer (BC) is paramount. We examined associations between two types of postdiagnosis physical activity (PA) and overall survival after BC. PATIENTS AND METHODS: We used prospective data on 959 BC survivors from the Diet, Cancer, and Health cohort, all enrolled before diagnosis. Self-reported PA was measured as time per activity, and estimated metabolic equivalent task (MET)-hours per week were summed for each activity. We constructed measures for household, exercise, and total PA. The association between postdiagnosis PA and all-cause mortality was estimated as hazard ratio (HRs) based on Cox proportional hazards model, with time since diagnosis as the underlying time scale. Prediagnosis PA, body mass index (BMI), and receptor status were examined as potential effect modifiers. RESULTS: We identified 144 deaths from all causes during the study period. In adjusted analyses, exercise PA above eight MET h/week compared to lower levels of activity was significantly associated with improved overall survival (HR, 0.68; confidence interval [CI]: 0.47-0.99). When comparing participation in exercise to non-participation, we found a 44% risk reduction in overall survival (HR, 0.56; CI: 0.33-0.95). Neither between household nor total PA and overall survival did, we find significant associations. Prediagnosis PA, BMI, and receptor status did not modify the effect significantly. CONCLUSION: Exercise PA corresponding to 2.5 h or more of brisk weekly walking after BC diagnosis may reduce mortality by up to 32% compared to low-level exercise. Participation in exercise PA may reduce mortality by 44% compared to non-participation.
Authors: Anne McTiernan; Christine M Friedenreich; Peter T Katzmarzyk; Kenneth E Powell; Richard Macko; David Buchner; Linda S Pescatello; Bonny Bloodgood; Bethany Tennant; Alison Vaux-Bjerke; Stephanie M George; Richard P Troiano; Katrina L Piercy Journal: Med Sci Sports Exerc Date: 2019-06 Impact factor: 5.411
Authors: Sine Rossen; Karen Trier; Berit Christensen; Martina A Eriksen; Ann-Dorthe Zwisler; Jette Vibe-Petersen Journal: Support Care Cancer Date: 2019-08-02 Impact factor: 3.603
Authors: Marta Smeda; Kamil Przyborowski; Bartosz Proniewski; Agnieszka Zakrzewska; Dawid Kaczor; Marta Stojak; Elzbieta Buczek; Zenon Nieckarz; Jerzy A Zoladz; Joanna Wietrzyk; Stefan Chlopicki Journal: Am J Cancer Res Date: 2017-09-01 Impact factor: 6.166
Authors: Rikki A Cannioto; Alan Hutson; Shruti Dighe; William McCann; Susan E McCann; Gary R Zirpoli; William Barlow; Kara M Kelly; Carol A DeNysschen; Dawn L Hershman; Joseph M Unger; Halle C F Moore; James A Stewart; Claudine Isaacs; Timothy J Hobday; Muhammad Salim; Gabriel N Hortobagyi; Julie R Gralow; Kathy S Albain; G Thomas Budd; Christine B Ambrosone Journal: J Natl Cancer Inst Date: 2021-01-04 Impact factor: 13.506
Authors: Alpa V Patel; Christine M Friedenreich; Steven C Moore; Sandra C Hayes; Julie K Silver; Kristin L Campbell; Kerri Winters-Stone; Lynn H Gerber; Stephanie M George; Janet E Fulton; Crystal Denlinger; G Stephen Morris; Trisha Hue; Kathryn H Schmitz; Charles E Matthews Journal: Med Sci Sports Exerc Date: 2019-11 Impact factor: 5.411
Authors: M Pollán; S Casla-Barrio; J Alfaro; C Esteban; M A Segui-Palmer; A Lucia; M Martín Journal: Clin Transl Oncol Date: 2020-02-13 Impact factor: 3.405
Authors: Theresa Westphal; Gabriel Rinnerthaler; Simon Peter Gampenrieder; Josef Niebauer; Josef Thaler; Michael Pfob; David Fuchs; Marina Riedmann; Barbara Mayr; Bernhard Reich; Thomas Melchardt; Brigitte Mlineritsch; Lisa Pleyer; Richard Greil Journal: Cancer Med Date: 2018-11-10 Impact factor: 4.452