Literature DB >> 27529471

Upregulation of an Artificial Zymogen by Proteolysis.

Zhe Liu1,2, Vincent Lebrun1, Taku Kitanosono3, Hendrik Mallin1, Valentin Köhler1, Daniel Häussinger1, Donald Hilvert4, Shu Kobayashi3, Thomas R Ward5.   

Abstract

Regulation of enzymatic activity is vital to living organisms. Here, we report the development and the genetic optimization of an artificial zymogen requiring the action of a natural protease to upregulate its latent asymmetric transfer hydrogenase activity.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:  artificial metalloenzyme; artificial zymogen; asymmetric catalysis; transfer hydrogenation; upregulation

Mesh：

Substances：

Year:  2016        PMID： 27529471     DOI： 10.1002/anie.201605010

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  4 in total

1.  Novel iridium(III) iminopyridine complexes: synthetic, catalytic, and in vitro anticancer activity studies.

Authors:  Deliang Kong; Meng Tian; Lihua Guo; Xicheng Liu; Shumiao Zhang; Yameng Song; Xin Meng; Shu Wu; Lingzi Zhang; Zhe Liu
Journal:  J Biol Inorg Chem       Date:  2018-06-11       Impact factor: 3.358

Review 2.  Designed for life: biocompatible de novo designed proteins and components.

Authors:  Katie J Grayson; J L Ross Anderson
Journal:  J R Soc Interface       Date:  2018-08       Impact factor: 4.118

3.  LmrR: A Privileged Scaffold for Artificial Metalloenzymes.

Authors:  Gerard Roelfes
Journal:  Acc Chem Res       Date:  2019-02-22       Impact factor: 22.384

Review 4.  Artificial Metalloenzymes: Challenges and Opportunities.

Authors:  Holly J Davis; Thomas R Ward
Journal:  ACS Cent Sci       Date:  2019-07-16       Impact factor: 14.553
  4 in total

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