BACKGROUND: Extraskeletal osteosarcoma is a rare tumor with a poor prognosis. The purpose of this study is to examine the oncologic outcomes of this disease as they relate to surgical treatment and use of adjuvant therapies. METHODS: We retrospectively analyzed all patients treated at our institution for high-grade extraskeletal osteosarcoma of the limb or chest wall. We recorded demographic data, presenting stage, surgical margin, use of adjuvant chemotherapy or radiation, incidence of local recurrence, metastases, and death. Overall and event-free survival were calculated using Kaplan-Meier survival methods. RESULTS: There were 12 patients treated with primary wide resection or re-excision of a previously operated tumor bed. Four patients presented with metastases. Seven patients received chemotherapy and four patients received radiation therapy. There were two local recurrences, six patients developed new metastases, and nine patients died. There was no difference in overall survival in patients who received chemotherapy. There was, however, a trend towards increased length of survival in patients who received chemotherapy compared to those who did not (16.4 months vs. 9.3 months, p=0.16). CONCLUSIONS: Despite no difference in overall survival, patients treated with adjuvant chemotherapy have a trend towards increased length of survival. We suggest that extraskeletal osteosarcoma be treated with standard osteosarcoma chemotherapy regimens in addition to wide resection.
BACKGROUND:Extraskeletal osteosarcoma is a rare tumor with a poor prognosis. The purpose of this study is to examine the oncologic outcomes of this disease as they relate to surgical treatment and use of adjuvant therapies. METHODS: We retrospectively analyzed all patients treated at our institution for high-grade extraskeletal osteosarcoma of the limb or chest wall. We recorded demographic data, presenting stage, surgical margin, use of adjuvant chemotherapy or radiation, incidence of local recurrence, metastases, and death. Overall and event-free survival were calculated using Kaplan-Meier survival methods. RESULTS: There were 12 patients treated with primary wide resection or re-excision of a previously operated tumor bed. Four patients presented with metastases. Seven patients received chemotherapy and four patients received radiation therapy. There were two local recurrences, six patients developed new metastases, and nine patients died. There was no difference in overall survival in patients who received chemotherapy. There was, however, a trend towards increased length of survival in patients who received chemotherapy compared to those who did not (16.4 months vs. 9.3 months, p=0.16). CONCLUSIONS: Despite no difference in overall survival, patients treated with adjuvant chemotherapy have a trend towards increased length of survival. We suggest that extraskeletal osteosarcoma be treated with standard osteosarcoma chemotherapy regimens in addition to wide resection.
Authors: Syed A Ahmad; Shreyaskumar R Patel; Matthew T Ballo; Treneth P Baker; Alan W Yasko; Xuemei Wang; Barry W Feig; Kelly K Hunt; Patrick P Lin; Kristen L Weber; Lei L Chen; Gunar K Zagars; Raphael E Pollock; Robert S Benjamin; Peter W T Pisters Journal: J Clin Oncol Date: 2002-01-15 Impact factor: 44.544
Authors: Sing Yu Goldstein-Jackson; Georg Gosheger; Günter Delling; Wolfgang E Berdel; G Ulrich Exner; Gernot Jundt; Jan-Nicolas Machatschek; Andreas Zoubek; Heribert Jürgens; Stefan S Bielack Journal: J Cancer Res Clin Oncol Date: 2005-05-26 Impact factor: 4.553
Authors: Adel Mahjoub; Alejandro Morales-Restrepo; Mitchell S Fourman; Jonathan B Mandell; Lu Feiqi; Margaret L Hankins; Rebecca J Watters; Kurt R Weiss Journal: Ann Surg Oncol Date: 2018-12-27 Impact factor: 5.344