Literature DB >> 27528750

The role of Trim25 in development, disease and RNA metabolism.

Gregory Heikel1, Nila Roy Choudhury1, Gracjan Michlewski2.   

Abstract

Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of pre-let-7. Here we review the current knowledge of the role of Trim25 in development, disease and RNA metabolism.
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.

Entities:  

Keywords:  E3 ubiquitin ligase; RNA metabolism; Trim25; novel RNA-binding proteins

Mesh：

Substances：

Year:  2016        PMID： 27528750     DOI： 10.1042/BST20160077

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  15 in total

Review 1.  The roles of E3 ligases in Hepatocellular carcinoma.

Authors:  Zongdong Yu; Hong Li; Jie Zhu; Haibiao Wang; Xiaofeng Jin
Journal:  Am J Cancer Res       Date:  2022-03-15       Impact factor: 6.166

2.  Tripartite motif-containing 25 facilitates immunosuppression and inhibits apoptosis of glioma via activating NF-κB.

Authors:  Mao-Xu Ge; Yi-Kang Shi; Dong Liu
Journal:  Exp Biol Med (Maywood)       Date:  2022-06-20

3.  TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense.

Authors:  Jacint G Sanchez; Konstantin M J Sparrer; Cindy Chiang; Rebecca A Reis; Jessica J Chiang; Matthew A Zurenski; Yueping Wan; Michaela U Gack; Owen Pornillos
Journal:  J Mol Biol       Date:  2018-10-17       Impact factor: 5.469

Review 4.  TRIM25 in the Regulation of the Antiviral Innate Immunity.

Authors:  María Martín-Vicente; Luz M Medrano; Salvador Resino; Adolfo García-Sastre; Isidoro Martínez
Journal:  Front Immunol       Date:  2017-09-22       Impact factor: 7.561

Review 5.  The TRIMendous Role of TRIMs in Virus-Host Interactions.

Authors:  Sarah van Tol; Adam Hage; Maria Isabel Giraldo; Preeti Bharaj; Ricardo Rajsbaum
Journal:  Vaccines (Basel)       Date:  2017-08-22

6.  The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasome-mediated degradation of PPARγ.

Authors:  Jae Min Lee; Sun Sil Choi; Yo Han Lee; Keon Woo Khim; Sora Yoon; Byung-Gyu Kim; Dougu Nam; Pann-Ghill Suh; Kyungjae Myung; Jang Hyun Choi
Journal:  Exp Mol Med       Date:  2018-10-15       Impact factor: 8.718

7.  Disease classification via gene network integrating modules and pathways.

Authors:  Zhilong Mi; Binghui Guo; Ziqiao Yin; Jiahui Li; Zhiming Zheng
Journal:  R Soc Open Sci       Date:  2019-07-17       Impact factor: 2.963

8.  Nucleocapsid protein of porcine reproductive and respiratory syndrome virus antagonizes the antiviral activity of TRIM25 by interfering with TRIM25-mediated RIG-I ubiquitination.

Authors:  Kuan Zhao; Li-Wei Li; Yi-Feng Jiang; Fei Gao; Yu-Jiao Zhang; Wen-Ying Zhao; Guo-Xin Li; Ling-Xue Yu; Yan-Jun Zhou; Guang-Zhi Tong
Journal:  Vet Microbiol       Date:  2019-05-03       Impact factor: 3.293

9.  Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis.

Authors:  Usman Nasrullah; Kristina Haeussler; Abhiruchi Biyanee; Ilka Wittig; Josef Pfeilschifter; Wolfgang Eberhardt
Journal:  Cells       Date:  2019-12-12       Impact factor: 6.600

10.  RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination.

Authors:  Nila Roy Choudhury; Gregory Heikel; Maryia Trubitsyna; Peter Kubik; Jakub Stanislaw Nowak; Shaun Webb; Sander Granneman; Christos Spanos; Juri Rappsilber; Alfredo Castello; Gracjan Michlewski
Journal:  BMC Biol       Date:  2017-11-08       Impact factor: 7.431
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