Literature DB >> 27527089

Correlation of Checkerboard Synergy Testing with Time-Kill Analysis and Clinical Outcomes of Extensively Drug-Resistant Acinetobacter baumannii Respiratory Infections.

Derek N Bremmer1, Karri A Bauer1, Stephanie M Pouch2, Keelie Thomas3, Debra Smith3, Debra A Goff1, Preeti Pancholi3, Joan-Miquel Balada-Llasat4.   

Abstract

We tested 76 extensively drug-resistant (XDR) Acinetobacter baumannii isolates by the checkerboard method using only wells containing serum-achievable concentrations (SACs) of drugs. Checkerboard results were correlated by time-kill assay and clinical outcomes. Minocycline-colistin was the best combination in vitro, as it inhibited growth in one or more SAC wells in all isolates. Patients who received a combination that inhibited growth in one or more SAC wells demonstrated better microbiological clearance than those who did not (88% versus 30%; P = 0.025). The checkerboard platform may have clinical utility for XDR A. baumannii infections.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27527089      PMCID： PMC5075101          DOI： 10.1128/AAC.00981-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

Review 1.  Guidelines for the management of intravascular catheter-related infections.

Authors:  L A Mermel; B M Farr; R J Sherertz; I I Raad; N O'Grady; J S Harris; D E Craven
Journal:  Infect Control Hosp Epidemiol       Date:  2001-04       Impact factor: 3.254

2.  Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia.

Authors: 
Journal:  Am J Respir Crit Care Med       Date:  2005-02-15       Impact factor: 21.405

3.  In vitro activity of doripenem in combination with various antimicrobials against multidrug-resistant Acinetobacter baumannii: possible options for the treatment of complicated infection.

Authors:  Luigi Principe; Alessandro Capone; Antonio Mazzarelli; Silvia D'Arezzo; Eugenio Bordi; Antonino Di Caro; Nicola Petrosillo
Journal:  Microb Drug Resist       Date:  2013-05-09       Impact factor: 3.431

4.  Carbapenem-resistance in gram-negative bacilli and intravenous minocycline: an antimicrobial stewardship approach at the Detroit Medical Center.

Authors:  Jason M Pogue; Anupama Neelakanta; Ryan P Mynatt; Sarit Sharma; Paul Lephart; Keith S Kaye
Journal:  Clin Infect Dis       Date:  2014-12-01       Impact factor: 9.079

5.  In vitro synergy test of meropenem and sulbactam against clinical isolates of Acinetobacter baumannii.

Authors:  Carlos R V Kiffer; Jorge L M Sampaio; Sumiko Sinto; Carmen P Oplustil; Paula C M Koga; Andréa C Arruda; Philip J Turner; Caio Mendes
Journal:  Diagn Microbiol Infect Dis       Date:  2005-08       Impact factor: 2.803

6.  KPC-producing Klebsiella pneumoniae strains that harbor AAC(6')-Ib exhibit intermediate resistance to amikacin.

Authors:  Derek N Bremmer; Cornelius J Clancy; Ellen G Press; Reem Almaghrabi; Liang Chen; Yohei Doi; M Hong Nguyen; Ryan K Shields
Journal:  Antimicrob Agents Chemother       Date:  2014-10-06       Impact factor: 5.191

7.  Acinetobacter baumannii in critically ill patients: Molecular epidemiology, clinical features and predictors of mortality.

Authors:  José Garnacho-Montero; Antonio Gutiérrez-Pizarraya; Ana Díaz-Martín; José Miguel Cisneros-Herreros; María Eugenia Cano; Eva Gato; Carlos Ruiz de Alegría; Felipe Fernández-Cuenca; Jordi Vila; Luis Martínez-Martínez; M Del Mar Tomás-Carmona; Álvaro Pascual; Germán Bou; Jerónimo Pachón-Diaz; Jesús Rodríguez-Baño
Journal:  Enferm Infecc Microbiol Clin       Date:  2016-01-25       Impact factor: 1.731

8.  Excess Mortality Associated With Colistin-Tigecycline Compared With Colistin-Carbapenem Combination Therapy for Extensively Drug-Resistant Acinetobacter baumannii Bacteremia: A Multicenter Prospective Observational Study.

Authors:  Aristine Cheng; Yu-Chung Chuang; Hsin-Yun Sun; Wang-Huei Sheng; Chia-Jui Yang; Chun-Hsing Liao; Po-Ren Hsueh; Jia-Ling Yang; Ni-Jiin Shen; Jann-Tay Wang; Chien-Ching Hung; Yee-Chun Chen; Shan-Chwen Chang
Journal:  Crit Care Med       Date:  2015-06       Impact factor: 7.598

9.  In vitro Activity of Colistin in Combination with Tigecycline against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Patients with Ventilator-Associated Pneumonia.

Authors:  Aytekin Cikman; Baris Gulhan; Merve Aydin; Mehmet Resat Ceylan; Mehmet Parlak; Faruk Karakecili; Alper Karagoz
Journal:  Int J Med Sci       Date:  2015-08-14       Impact factor: 3.738

Review 10.  Therapy of Infections due to Carbapenem-Resistant Gram-Negative Pathogens.

Authors:  Chang-Seop Lee; Yohei Doi
Journal:  Infect Chemother       Date:  2014-09-24
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  8 in total

1.  Pharmacodynamic Attainment of the Synergism of Meropenem and Fosfomycin Combination against Pseudomonas aeruginosa Producing Metallo-β-Lactamase.

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Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

2.  Small Molecule Adjuvants Potentiate Colistin Activity and Attenuate Resistance Development in Escherichia coli by Affecting pmrAB System.

Authors:  Dipak Kathayat; Linto Antony; Loic Deblais; Yosra A Helmy; Joy Scaria; Gireesh Rajashekara
Journal:  Infect Drug Resist       Date:  2020-07-10       Impact factor: 4.003

3.  Structural insights into the combinatorial effects of antimicrobial peptides reveal a role of aromatic-aromatic interactions in antibacterial synergism.

Authors:  Humaira Ilyas; JaeWoong Kim; DongKuk Lee; Martin Malmsten; Anirban Bhunia
Journal:  J Biol Chem       Date:  2019-08-05       Impact factor: 5.157

4.  Assessment of the in vitro activity of azithromycin niosomes alone and in combination with levofloxacin on extensively drug-resistant Klebsiella pneumoniae clinical isolates.

Authors:  Hoda Mohamed Owais; Manal Mohammad Baddour; Hala Abd El-Raouf El-Metwally; Heba Soliman Barakat; Nour Sherif Ammar; Marwa Ahmed Meheissen
Journal:  Braz J Microbiol       Date:  2021-01-22       Impact factor: 2.476

5.  Photoinactivation of catalase sensitizes a wide range of bacteria to ROS-producing agents and immune cells.

Authors:  Pu-Ting Dong; Sebastian Jusuf; Jie Hui; Yuewei Zhan; Yifan Zhu; George Y Liu; Ji-Xin Cheng
Journal:  JCI Insight       Date:  2022-05-23

Review 6.  Anticipating the Unpredictable: A Review of Antimicrobial Stewardship and Acinetobacter Infections.

Authors:  Eric Wenzler; Debra A Goff; Romney Humphries; Ellie J C Goldstein
Journal:  Infect Dis Ther       Date:  2017-03-04

7.  Choice of therapeutic interventions and outcomes for the treatment of infections caused by multidrug-resistant gram-negative pathogens: a systematic review.

Authors:  Sarah Melissa Nørgaard; Camilla Skaarup Jensen; Josefine Aalestrup; Christina M J E Vandenbroucke-Grauls; Mark G J de Boer; Alma Becic Pedersen
Journal:  Antimicrob Resist Infect Control       Date:  2019-11-04       Impact factor: 4.887

8.  TP0586532, a Novel Non-Hydroxamate LpxC Inhibitor: Potentiating Effect on In Vitro Activity of Meropenem against Carbapenem-Resistant Enterobacteriaceae.

Authors:  Ippei Yoshida; Iichiro Takata; Kiyoko Fujita; Hajime Takashima; Hiroyuki Sugiyama
Journal:  Microbiol Spectr       Date:  2022-06-01
  8 in total

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