| Literature DB >> 27526706 |
Shveta S Motwani1,2, Leal Herlitz3, Divya Monga4, Kenar D Jhaveri5, Albert Q Lam6,2.
Abstract
Paraproteins are monoclonal Igs that accumulate in blood as a result of abnormal excess production. These circulating proteins cause a diversity of kidney disorders that are increasingly being comanaged by nephrologists. In this review, we discuss paraprotein-related diseases that affect the glomerulus. We provide a broad overview of diseases characterized by nonorganized deposits, such as monoclonal Ig deposition disease (MIDD), proliferative GN with monoclonal Ig deposits (PGNMID), and C3 glomerulopathy, as well as those characterized by organized deposits, such as amyloidosis, immunotactoid glomerulopathy, fibrillary GN, and cryoglobulinemic GN, and rarer disorders, such as monoclonal crystalline glomerulopathies, paraprotein-related thrombotic microangiopathies, and membranous-like glomerulopathy with masked IgGκ deposits. This review will provide the nephrologist with an up to date understanding of these entities and highlight the areas of deficit in evidence and future lines of research.Entities:
Keywords: Amyloidosis; Immunoglobulin G; Kidney Glomerulus; Paraproteinemias; Paraproteins; Thrombotic Microangiopathies; amyloidosis; cancer; cryoglobulinemia; fibrillary glomerulonephritis; glomerular disease; glomerulonephritis; immunotactoid glomerulopathy; light chain deposition disease; multiple myeloma; nephrotic syndrome
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Year: 2016 PMID： 27526706 PMCID： PMC5142064 DOI： 10.2215/CJN.02980316
Source DB: PubMed Journal: Clin J Am Soc Nephrol ISSN： 1555-9041 Impact factor: 8.237