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Literature DB >> 27526290

Runx2 and microRNA regulation in bone and cartilage diseases.

Weiwei Zhao^1,2, Shanxing Zhang¹, Baoli Wang³, Jian Huang¹, William W Lu², Di Chen¹.

Abstract

The homeostasis of skeletal tissues requires tight regulation of a variety of signaling pathways, and the onset and progression of skeletal diseases are often caused by signaling abnormalities. MicroRNAs (miRNAs) are short noncoding RNA molecules that have emerged as a new dimension of gene regulation. MiRNAs have been shown to play an important role in the regulation of the differentiation of embryonic and hematopoietic stem cells. However, the role of specific miRNAs and their target genes has not been fully defined in the regulation of mesenchymal stem cells. Runx2 is a key transcription factor controlling MSC differentiation and bone and cartilage function. This article reviews work on Runx2 and miRNA regulation in bone and cartilage diseases.

Entities: CellLine Chemical Disease Gene Species

Keywords: Runx2; bone; cartilage; microRNA

Mesh：

Substances：

Year: 2016 PMID： 27526290 PMCID： PMC5118124 DOI： 10.1111/nyas.13206

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

57 in total

Review 1. The widespread regulation of microRNA biogenesis, function and decay.

Authors: Jacek Krol; Inga Loedige; Witold Filipowicz
Journal: Nat Rev Genet Date: 2010-07-27 Impact factor: 53.242

2. Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).

Authors: Aida Martinez-Sanchez; Katarzyna A Dudek; Chris L Murphy
Journal: J Biol Chem Date: 2011-11-18 Impact factor: 5.157

3. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion.

Authors: Jitesh Pratap; Amjad Javed; Lucia R Languino; Andre J van Wijnen; Janet L Stein; Gary S Stein; Jane B Lian
Journal: Mol Cell Biol Date: 2005-10 Impact factor: 4.272

4. Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage.

Authors: Xibin Wang; Paul A Manner; Alan Horner; Lillian Shum; Rocky S Tuan; Glen H Nuckolls
Journal: Osteoarthritis Cartilage Date: 2004-12 Impact factor: 6.576

5. MiR-23a functions as a tumor suppressor in osteosarcoma.

Authors: Yu He; Chunqing Meng; Zengwu Shao; Hong Wang; Shuhua Yang
Journal: Cell Physiol Biochem Date: 2014-10-08

6. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

Authors: Mei Zhu; Dezhi Tang; Qiuqian Wu; Suyang Hao; Mo Chen; Chao Xie; Randy N Rosier; Regis J O'Keefe; Michael Zuscik; Di Chen
Journal: J Bone Miner Res Date: 2009-01 Impact factor: 6.741

7. Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

Authors: Jie Shen; Jia Li; Baoli Wang; Hongting Jin; Meina Wang; Yejia Zhang; Yunzhi Yang; Hee-Jeong Im; Regis O'Keefe; Di Chen
Journal: Arthritis Rheum Date: 2013-12

Review 8. MicroRNAs: key regulators of stem cells.

Authors: Vamsi K Gangaraju; Haifan Lin
Journal: Nat Rev Mol Cell Biol Date: 2009-02 Impact factor: 94.444

9. MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation.

Authors: Jian Huang; Lan Zhao; Lianping Xing; Di Chen
Journal: Stem Cells Date: 2010-02 Impact factor: 6.277

10. Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification.

Authors: Joshua A F Balderman; Hae-Young Lee; Christopher E Mahoney; Diane E Handy; Kevin White; Sofia Annis; Djamel Lebeche; Roger J Hajjar; Joseph Loscalzo; Jane A Leopold
Journal: J Am Heart Assoc Date: 2012-12-19 Impact factor: 5.501

9 in total

Runx2 and microRNA regulation in bone and cartilage diseases.

Review 1. The widespread regulation of microRNA biogenesis, function and decay.

2. Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).

3. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion.

4. Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage.

5. MiR-23a functions as a tumor suppressor in osteosarcoma.

6. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

7. Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

Review 8. MicroRNAs: key regulators of stem cells.

9. MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation.

10. Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification.

1. Down-regulation of Noggin and miR-138 coordinately promote osteogenesis of mesenchymal stem cells.

Review 2. Runx2 plays a central role in Osteoarthritis development.

Review 3. Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis.

4. MICROmanagement of Runx2 Function in Skeletal Cells.

5. The biological response to laser-aided direct metal-coated Titanium alloy (Ti6Al4V).

6. High Expression of MicroRNA-196a is Associated with Progression of Hepatocellular Carcinoma in Younger Patients.

Review 7. Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications.

8. Overexpression Effects of miR-424 and BMP2 on the Osteogenesis of Wharton's Jelly-Derived Stem Cells.

9. Identification of neoplasm-specific signatures of miRNA interactions by employing a systems biology approach.