| Literature DB >> 27526169 |
Rongwen Tain1, He N Xu2, Xiaohong J Zhou1, Lin Z Li3, Kejia Cai4.
Abstract
Developing imaging biomarkers for non-invasive measurement of the tissue redox state is a key research area. Recently, we presented the first non-invasive MR imaging method that demonstrated the correlation between the endogenous chemical exchange saturation transfer (CEST) contrast and the tissue redox state. It is well known that the broadband magnetization transfer (MT) can occur via chemical exchange (CEST) and/or dipole-dipole interactions. The present study investigated if the broadband MT also correlated with the tissue redox state. The preliminary result for the prostate tumor xenografts indeed showed a significant correlation between the broadband MT contrast and the NADH redox ratio quantified with the optical redox scanning. In vivo MT contrast, once calibrated, may potentially serve as an imaging biomarker for tissue redox state.Entities:
Keywords: CEST; MRI; Magnetization transfer; Oxidative stress; Prostate cancer; Redox state
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Year: 2016 PMID： 27526169 PMCID： PMC5411113 DOI： 10.1007/978-3-319-38810-6_52
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622