Literature DB >> 2752373

No amplification or rearrangement of INT1, GLI, or COL2A1 in uterine leiomyomas with t(12;14)(q14-15;q23-24).

K Arheden1, M Nilbert, S Heim, N Mandahl, F Mitelman.   

Abstract

We have studied three uterine leiomyoma tumors, all previously cytogenetically analyzed and shown to have the clonal abnormality t(12:14)(q14-15;q23-24), with the purpose of detecting amplification or rearrangement of three genes that are localized close to the 12q breakpoint region. The genes studied were the two putative oncogenes INT1 and GLI, and the collagen type II alpha 1 gene, COL2A1. No rearrangement or amplification could be detected for any of the three gene sequences.

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Year:  1989        PMID： 2752373     DOI： 10.1016/0165-4608(89)90186-6

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  3 in total

1.  Characteristic chromosome abnormalities, including rearrangements of 6p, del(7q), +12, and t(12;14), in 44 uterine leiomyomas.

Authors:  M Nilbert; S Heim; N Mandahl; U M Flodérus; H Willén; F Mitelman
Journal:  Hum Genet       Date:  1990-10       Impact factor: 4.132

2.  The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases.

Authors:  Hu Zhu; Hui-Wen Lo
Journal:  Curr Genomics       Date:  2010-06       Impact factor: 2.236

3.  Allelic deletions in the long arm of chromosome 12 identify sites of candidate tumor suppressor genes in male germ cell tumors.

Authors:  V V Murty; J Houldsworth; S Baldwin; V Reuter; W Hunziker; P Besmer; G Bosl; R S Chaganti
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205
  3 in total

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