Literature DB >> 27523394

Role of AhR in positive regulation of cell proliferation and survival.

Jiuheng Yin1, Baifa Sheng1, Yuan Qiu1, Kunqiu Yang1, Weidong Xiao2, Hua Yang3.   

Abstract

The aryl hydrocarbon receptor (AhR) is an important nuclear transcription factor that is best known for mediating toxic responses by adjusting numbers of metabolism-related enzymes, including CYP1A1 and CYP1B1. Previous findings have revealed that, in addition to negatively regulating cell proliferation and survival, AhR may also positively regulate these pathways. Here, we review these findings and summarize distinct mechanisms by which AhR promotes cell proliferation and survival, including modulation of receptor expression, growth factor signalling and apoptosis, regulating the cell cycle and promoting cytokine expression. This review will aid better understanding the role of AhR in positive regulation of cell proliferation and survival.
© 2016 John Wiley & Sons Ltd.

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Year:  2016        PMID： 27523394      PMCID： PMC6496171          DOI： 10.1111/cpr.12282

Source DB:  PubMed          Journal:  Cell Prolif        ISSN： 0960-7722            Impact factor:   6.831


  77 in total

1.  Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes.

Authors:  Cedric Vonarbourg; Arthur Mortha; Viet L Bui; Pedro P Hernandez; Elina A Kiss; Thomas Hoyler; Melanie Flach; Bertram Bengsch; Robert Thimme; Christoph Hölscher; Manfred Hönig; Ulrich Pannicke; Klaus Schwarz; Carl F Ware; Daniela Finke; Andreas Diefenbach
Journal:  Immunity       Date:  2010-11-24       Impact factor: 31.745

2.  Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade.

Authors:  Mingcan Xia; Loida Viera-Hutchins; Maria Garcia-Lloret; Magali Noval Rivas; Petra Wise; Sean A McGhee; Zena K Chatila; Nancy Daher; Constantinos Sioutas; Talal A Chatila
Journal:  J Allergy Clin Immunol       Date:  2015-03-29       Impact factor: 10.793

3.  IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors.

Authors:  Naoko Satoh-Takayama; Sarah Lesjean-Pottier; Paulo Vieira; Shinichiro Sawa; Gerard Eberl; Christian A J Vosshenrich; James P Di Santo
Journal:  J Exp Med       Date:  2010-02-08       Impact factor: 14.307

4.  TCDD promoted EMT of hFPECs via AhR, which involved the activation of EGFR/ERK signaling.

Authors:  Zhan Gao; Yongjun Bu; Xiaozhuan Liu; Xugang Wang; Guofu Zhang; Erhui Wang; Shibin Ding; Yongfeng Liu; Ruling Shi; Qiaoyun Li; Jianhong Fu; Zengli Yu
Journal:  Toxicol Appl Pharmacol       Date:  2016-03-10       Impact factor: 4.219

5.  IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.

Authors:  Ken Sugimoto; Atsuhiro Ogawa; Emiko Mizoguchi; Yasuyo Shimomura; Akira Andoh; Atul K Bhan; Richard S Blumberg; Ramnik J Xavier; Atsushi Mizoguchi
Journal:  J Clin Invest       Date:  2008-02       Impact factor: 14.808

6.  Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

Authors:  Tejas S Lahoti; Jarod M Hughes; Ann Kusnadi; Kaarthik John; Bokai Zhu; Iain A Murray; Krishne Gowda; Jeffrey M Peters; Shantu G Amin; Gary H Perdew
Journal:  J Pharmacol Exp Ther       Date:  2013-12-05       Impact factor: 4.030

7.  2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced activation of mitogen-activated protein kinase signaling pathway in Jurkat T cells.

Authors:  Myung-Ja Kwon; Kyu-Shik Jeong; Eun Jeong Choi; Byung Ho Lee
Journal:  Pharmacol Toxicol       Date:  2003-10

Review 8.  Aryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation.

Authors:  Ju Qiu; Liang Zhou
Journal:  Semin Immunopathol       Date:  2013-08-23       Impact factor: 9.623

9.  Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling.

Authors:  Laura MacPherson; Shaimaa Ahmed; Laura Tamblyn; Jean Krutmann; Irmgard Förster; Heike Weighardt; Jason Matthews
Journal:  Int J Mol Sci       Date:  2014-05-06       Impact factor: 5.923

10.  Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells.

Authors:  Cristina Florean; Michael Schnekenburger; Jin-Young Lee; Kyung Rok Kim; Aloran Mazumder; Sungmi Song; Jae-Myun Kim; Cindy Grandjenette; Jeoung-Gyun Kim; Ah-Young Yoon; Mario Dicato; Kyu-Won Kim; Christo Christov; Byung-Woo Han; Peter Proksch; Marc Diederich
Journal:  Oncotarget       Date:  2016-04-26
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  17 in total

1.  Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity.

Authors:  Naoko Nakano; Nobuo Sakata; Yuki Katsu; Daiki Nochise; Erika Sato; Yuta Takahashi; Saori Yamaguchi; Yoko Haga; Souichi Ikeno; Mitsuyoshi Motizuki; Keigo Sano; Kohei Yamasaki; Keiji Miyazawa; Susumu Itoh
Journal:  J Biol Chem       Date:  2020-05-14       Impact factor: 5.157

2.  Does the Aryl Hydrocarbon Receptor Regulate Pluripotency?

Authors:  Chia-I Ko; Alvaro Puga
Journal:  Curr Opin Toxicol       Date:  2017-01-21

3.  Quercetin Reduces the Development of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Cleft Palate in Mice by Suppressing CYP1A1 via the Aryl Hydrocarbon Receptor.

Authors:  Keisuke Satake; Takenobu Ishii; Taiki Morikawa; Teruo Sakamoto; Yasushi Nishii
Journal:  Nutrients       Date:  2022-06-13       Impact factor: 6.706

4.  Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs).

Authors:  Wade W Sugden; Roberto C Leonardo-Mendonça; Darío Acuña-Castroviejo; Arndt F Siekmann
Journal:  PLoS One       Date:  2017-08-17       Impact factor: 3.240

5.  The Satellite Cell Niche Regulates the Balance between Myoblast Differentiation and Self-Renewal via p53.

Authors:  Valentina Flamini; Rachel S Ghadiali; Philipp Antczak; Amy Rothwell; Jeremy E Turnbull; Addolorata Pisconti
Journal:  Stem Cell Reports       Date:  2018-02-08       Impact factor: 7.765

6.  SIVcpz closely related to the ancestral HIV-1 is less or non-pathogenic to humans in a hu-BLT mouse model.

Authors:  Zhe Yuan; Guobin Kang; Lance Daharsh; Wenjin Fan; Qingsheng Li
Journal:  Emerg Microbes Infect       Date:  2018-04-04       Impact factor: 7.163

7.  Indoxyl Sulfate Promotes Macrophage IL-1β Production by Activating Aryl Hydrocarbon Receptor/NF-κ/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated.

Authors:  Takuya Wakamatsu; Suguru Yamamoto; Toru Ito; Yoko Sato; Koji Matsuo; Yoshimitsu Takahashi; Yoshikatsu Kaneko; Shin Goto; Junichiro James Kazama; Fumitake Gejyo; Ichiei Narita
Journal:  Toxins (Basel)       Date:  2018-03-15       Impact factor: 4.546

Review 8.  Xenobiotic Receptors and Their Mates in Atopic Dermatitis.

Authors:  Deborah Minzaghi; Petra Pavel; Sandrine Dubrac
Journal:  Int J Mol Sci       Date:  2019-08-29       Impact factor: 5.923

9.  TRPV1 Hyperfunction Involved in Uremic Toxin Indoxyl Sulfate-Mediated Renal Tubular Damage.

Authors:  Chien-Lin Lu; Chun-Hou Liao; Kuo-Cheng Lu; Ming-Chieh Ma
Journal:  Int J Mol Sci       Date:  2020-08-27       Impact factor: 5.923

10.  Activation of aryl hydrocarbon receptor by 6-formylindolo[3,2-b]carbazole alleviated acute kidney injury by repressing inflammation and apoptosis.

Authors:  Sibei Tao; Fan Guo; Qian Ren; Jing Liu; Tiantian Wei; Lingzhi Li; Liang Ma; Ping Fu
Journal:  J Cell Mol Med       Date:  2020-12-06       Impact factor: 5.295
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