Ying Han1,2, Jing Wang3, Liping Hong4, Leina Sun4, Hongqing Zhuang5, Bingsheng Sun6, Hua Wang7, Xinwei Zhang1,2, Xiubao Ren1,2. 1. Department of Immunology, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin, PR China. 2. Biotherapy Center, Key Laboratory of Cancer Immunology & Biotherapy, Tianjin Medical University Cancer Institute & Hospital, Tianjin, PR China. 3. Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, PR China. 4. Department of Pathology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, PR China. 5. Department of Radiotherapy, Tianjin Medical University Cancer Institute & Hospital, Tianjin, PR China. 6. Department of Lung Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin, PR China. 7. Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, PR China.
Abstract
AIM: As the prognostic value of the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is unclear in patients with ALK-positive non-small-cell lung cancer (NSCLC), this study assessed the importance of these factors was in this patient subset. PATIENTS & METHODS: In 173 patients with primary ALK-positive NSCLC at pathological stages I-IV, neutrophil, platelet, lymphocyte, D-dimer and eosinophil levels were recorded before starting treatment. RESULTS: The patients' median NLR and PLR values were 2.10 and 127.69, respectively. Univariate analyses showed that NLR and PLR values, the D-dimer level and the eosinophil count were all associated with survival. Although multivariate analysis showed PLR to be an independent prognostic factor for overall survival (p = 0.018), NLR was not. CONCLUSION: PLR is an independent prognostic factor in ALK-positive NSCLC.
AIM: As the prognostic value of the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is unclear in patients with ALK-positive non-small-cell lung cancer (NSCLC), this study assessed the importance of these factors was in this patient subset. PATIENTS & METHODS: In 173 patients with primary ALK-positive NSCLC at pathological stages I-IV, neutrophil, platelet, lymphocyte, D-dimer and eosinophil levels were recorded before starting treatment. RESULTS: The patients' median NLR and PLR values were 2.10 and 127.69, respectively. Univariate analyses showed that NLR and PLR values, the D-dimer level and the eosinophil count were all associated with survival. Although multivariate analysis showed PLR to be an independent prognostic factor for overall survival (p = 0.018), NLR was not. CONCLUSION: PLR is an independent prognostic factor in ALK-positive NSCLC.