T Ruggiero1, E Burdino2, A Calcagno3, S Bonora3, L Boglione3, G Di Perri3, V Ghisetti2. 1. Laboratory of Microbiology and Virology, Department of Infectious Diseases, Amedeo di Savoia Hospital, Corso Svizzera 164, 10149, Turin, Italy. tinarugg@gmail.com. 2. Laboratory of Microbiology and Virology, Department of Infectious Diseases, Amedeo di Savoia Hospital, Corso Svizzera 164, 10149, Turin, Italy. 3. Unit of Infectious Diseases, Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, Turin, Italy.
Abstract
PURPOSE: Data on the frequency of HCV naturally occurring drug-resistant variants (RAVs) at baseline in HIV/HCV coinfected patients are scarce. METHODS: NS3-HCV RAVs were studied by full-population direct sequencing from plasma specimens of 345 DAA-naïve patients with HCV chronic hepatitis (159 of them with HIV/HCV-coinfection). RESULTS: NS3 RAVs were identified in 31.5 % of patients, with a significant proportion of HIV/HCV coinfected DAA-naïve patients compared to those with HCV monoinfection (38 vs. 25 % p = 0.0104, OR 1.84; 95 % CI 1.162-2.916). CONCLUSIONS: HCV resistance genotyping test before treatment may be worth in special populations such as HIV/HCV coinfection to optimize patient treatment.
PURPOSE: Data on the frequency of HCV naturally occurring drug-resistant variants (RAVs) at baseline in HIV/HCV coinfectedpatients are scarce. METHODS:NS3-HCV RAVs were studied by full-population direct sequencing from plasma specimens of 345 DAA-naïve patients with HCV chronic hepatitis (159 of them with HIV/HCV-coinfection). RESULTS:NS3 RAVs were identified in 31.5 % of patients, with a significant proportion of HIV/HCV coinfectedDAA-naïve patients compared to those with HCV monoinfection (38 vs. 25 % p = 0.0104, OR 1.84; 95 % CI 1.162-2.916). CONCLUSIONS: HCV resistance genotyping test before treatment may be worth in special populations such as HIV/HCV coinfection to optimize patient treatment.
Entities:
Keywords:
DAAs; HIV/HCV coinfected; Hepatitis C virus; RAVs
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