Literature DB >> 27521367

Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.

Anja Lüdtke1, Paula Ruibal1, Beate Becker-Ziaja2, Monika Rottstegge3, David M Wozniak2, Mar Cabeza-Cabrerizo4, Anja Thorenz5, Romy Weller6, Romy Kerber2, Juliana Idoyaga7, N'Faly Magassouba8, Martin Gabriel2, Stephan Günther2, Lisa Oestereich2, César Muñoz-Fontela1.   

Abstract

A number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized by reduced levels of circulating nonclassical CD16+ monocytes with a poor activation profile. In survivors, CD16+ monocytes were activated during recovery, coincident with viral clearance, suggesting an important role of this cell subset in EVD pathophysiology.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Entities:  

Keywords:  CD14; CD16; Ebola virus; Ebola virus disease; monocytes

Mesh：

Substances：

Year:  2016        PMID： 27521367     DOI： 10.1093/infdis/jiw260

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  21 in total

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