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Literature DB >> 27521359

Zika Virus-Induced Antibody Response Enhances Dengue Virus Serotype 2 Replication In Vitro.

Anna B Kawiecki¹, Rebecca C Christofferson¹.

Abstract

Zika virus has emerged in the Americas, where dengue virus is endemic. Among the 4 serotypes of dengue virus, antibody-dependent enhancement is thought to enhance viral replication and disease severity. Reports suggest that anti-dengue virus antibody may enhance Zika virus replication. We investigated whether Zika virus antibodies enhance dengue virus replication, by exposing C57Bl/6 mice to Zika virus. Polyclonal serum was verified for strong Zika virus-neutralizing, dengue virus-subneutralizing capacity. Then we determined the enhancement capabilities of Zika virus-immune serum for dengue virus in vitro. We showed that Zika virus antibodies have the ability to enhance dengue virus infections, which is important, because in many Zika virus-affected areas, dengue virus is expected to remain endemic.

Entities: Disease Species

Keywords: Zika; antibody; antibody dependent enhancement; dengue; enhancement; plaque reduction neutralization test (PRNT)

Mesh：

Substances：

Year: 2016 PMID： 27521359 DOI： 10.1093/infdis/jiw377

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

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Cited

63 in total

1. A Vesicular Stomatitis Virus-Based Vaccine Carrying Zika Virus Capsid Protein Protects Mice from Viral Infection.

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Journal: Virol Sin Date: 2019-02-28 Impact factor: 4.327

2. A new class of broadly neutralizing antibodies that target the glycan loop of Zika virus envelope protein.

Authors: Panke Qu; Chao Zhang; Min Li; Weimin Ma; Pei Xiong; Qingwei Liu; Gang Zou; Dimitri Lavillette; Feifei Yin; Xia Jin; Zhong Huang
Journal: Cell Discov Date: 2020-02-04 Impact factor: 10.849

3. Maternally Acquired Zika Antibodies Enhance Dengue Disease Severity in Mice.

Authors: Angela M Fowler; William W Tang; Matthew P Young; Anila Mamidi; Karla M Viramontes; Melanie D McCauley; Aaron F Carlin; Robert T Schooley; Jesica Swanstrom; Ralph S Baric; Jennifer Govero; Michael S Diamond; Sujan Shresta
Journal: Cell Host Microbe Date: 2018-11-14 Impact factor: 21.023

Review 4. Using Macaques to Address Critical Questions in Zika Virus Research.

Authors: Dawn M Dudley; Matthew T Aliota; Emma L Mohr; Christina M Newman; Thaddeus G Golos; Thomas C Friedrich; David H O'Connor
Journal: Annu Rev Virol Date: 2019-06-10 Impact factor: 10.431

5. Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors.

Authors: Thomas F Rogers; Eileen C Goodwin; Bryan Briney; Devin Sok; Nathan Beutler; Alexander Strubel; Rebecca Nedellec; Khoa Le; Michael E Brown; Dennis R Burton; Laura M Walker
Journal: Sci Immunol Date: 2017-08-18

6. A relevant in vitro human model for the study of Zika virus antibody-dependent enhancement.

Authors: Berlin Londono-Renteria; Andrea Troupin; Jenny C Cardenas; Alex Hall; Omar G Perez; Lucio Cardenas; Adam Hartstone-Rose; Scott B Halstead; Tonya M Colpitts
Journal: J Gen Virol Date: 2017-07-08 Impact factor: 3.891

7. A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum.

Authors: William G Valiant; Joseph J Mattapallil
Journal: J Vis Exp Date: 2018-04-10 Impact factor: 1.355