Literature DB >> 27521191

Neuropathophysiology of Brain Injury.

Nidia Quillinan1, Paco S Herson2, Richard J Traystman3.   

Abstract

Every year in the United States, millions of individuals incur ischemic brain injury from stroke, cardiac arrest, or traumatic brain injury. These acquired brain injuries can lead to death or long-term neurologic and neuropsychological impairments. The mechanisms of ischemic and traumatic brain injury that lead to these deficiencies result from a complex interplay of interdependent molecular pathways, including excitotoxicity, acidotoxicity, ionic imbalance, oxidative stress, inflammation, and apoptosis. This article reviews several mechanisms of brain injury and discusses recent developments. Although much is known from animal models of injury, it has been difficult to translate these effects to humans.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Apoptosis; Excitotoxicity; Mechanisms of ischemic brain injury; Neuroinflammation; Neurovascular unit; Oxidative stress; Synaptic plasticity; Translation

Mesh：

Substances：

Year:  2016        PMID： 27521191      PMCID： PMC5214884          DOI： 10.1016/j.anclin.2016.04.011

Source DB:  PubMed          Journal:  Anesthesiol Clin        ISSN： 1932-2275


  53 in total

1.  A new look at glutamate and ischemia: NMDA agonist improves long-term functional outcome in a rat model of stroke.

Authors:  Jasbeer Dhawan; Helene Benveniste; Zhongchi Luo; Marta Nawrocky; S David Smith; Anat Biegon
Journal:  Future Neurol       Date:  2011-11-01

Review 2.  Axonal pathology in traumatic brain injury.

Authors:  Victoria E Johnson; William Stewart; Douglas H Smith
Journal:  Exp Neurol       Date:  2012-01-20       Impact factor: 5.330

Review 3.  Role of oxidants in ischemic brain damage.

Authors:  P H Chan
Journal:  Stroke       Date:  1996-06       Impact factor: 7.914

4.  Brain-derived neurotrophic factor improves long-term potentiation and cognitive functions after transient forebrain ischemia in the rat.

Authors:  I Kiprianova; J Sandkühler; S Schwab; S Hoyer; M Spranger
Journal:  Exp Neurol       Date:  1999-10       Impact factor: 5.330

5.  The effects of delayed reduction of tonic inhibition on ischemic lesion and sensorimotor function.

Authors:  Evelyn M R Lake; Joydeep Chaudhuri; Lynsie Thomason; Rafal Janik; Milan Ganguly; Mary Brown; JoAnne McLaurin; Dale Corbett; Greg J Stanisz; Bojana Stefanovic
Journal:  J Cereb Blood Flow Metab       Date:  2015-05-13       Impact factor: 6.200

6.  Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke.

Authors:  Jeffrey L Saver; Mayank Goyal; Alain Bonafe; Hans-Christoph Diener; Elad I Levy; Vitor M Pereira; Gregory W Albers; Christophe Cognard; David J Cohen; Werner Hacke; Olav Jansen; Tudor G Jovin; Heinrich P Mattle; Raul G Nogueira; Adnan H Siddiqui; Dileep R Yavagal; Blaise W Baxter; Thomas G Devlin; Demetrius K Lopes; Vivek K Reddy; Richard du Mesnil de Rochemont; Oliver C Singer; Reza Jahan
Journal:  N Engl J Med       Date:  2015-04-17       Impact factor: 91.245

7.  Tissue plasminogen activator for acute ischemic stroke.

Authors: 
Journal:  N Engl J Med       Date:  1995-12-14       Impact factor: 91.245

8.  Early loss of pericytes and perivascular stromal cell-induced scar formation after stroke.

Authors:  Francisco Fernández-Klett; Jason R Potas; Diana Hilpert; Katja Blazej; Josefine Radke; Jojanneke Huck; Odilo Engel; Werner Stenzel; Guillem Genové; Josef Priller
Journal:  J Cereb Blood Flow Metab       Date:  2012-12-19       Impact factor: 6.200

9.  Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation.

Authors:  J E Orfila; K Shimizu; A K Garske; G Deng; J Maylie; R J Traystman; N Quillinan; J P Adelman; P S Herson
Journal:  Eur J Neurosci       Date:  2014-07-31       Impact factor: 3.386

10.  Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke.

Authors:  Andrew N Clarkson; Ben S Huang; Sarah E Macisaac; Istvan Mody; S Thomas Carmichael
Journal:  Nature       Date:  2010-11-03       Impact factor: 49.962
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  43 in total

1.  Up-regulation of FOS-like antigen 1 contributes to neuronal apoptosis in the cortex of rat following traumatic brain injury.

Authors:  Xide Xu; Rui Jiang; Peipei Gong; Qianqian Liu; Yinan Chen; Shiqiang Hou; Debin Yuan; Jiansheng Shi; Qing Lan
Journal:  Metab Brain Dis       Date:  2017-10-27       Impact factor: 3.584

Review 2.  Docosahexaenoic Acid: Outlining the Therapeutic Nutrient Potential to Combat the Prenatal Alcohol-Induced Insults on Brain Development.

Authors:  Bradley A Feltham; Xavier L Louis; Michael N A Eskin; Miyoung Suh
Journal:  Adv Nutr       Date:  2020-05-01       Impact factor: 8.701

3.  Neuron-Derived Plasma Exosome Proteins after Remote Traumatic Brain Injury.

Authors:  Edward J Goetzl; Carrie B Peltz; Maja Mustapic; Dimitrios Kapogiannis; Kristine Yaffe
Journal:  J Neurotrauma       Date:  2019-10-11       Impact factor: 5.269

4.  Protective Effects of Spatholobi Caulis Extract on Neuronal Damage and Focal Ischemic Stroke/Reperfusion Injury.

Authors:  Hee Ra Park; Heeeun Lee; Jung-Jin Lee; Nam-Hui Yim; Min-Jung Gu; Jin Yeul Ma
Journal:  Mol Neurobiol       Date:  2017-07-13       Impact factor: 5.590

5.  Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.

Authors:  Chung-Yang Yeh; Ashlyn M Bulas; Aubin Moutal; Jami L Saloman; Karen A Hartnett; Charles T Anderson; Thanos Tzounopoulos; Dandan Sun; Rajesh Khanna; Elias Aizenman
Journal:  J Neurosci       Date:  2017-05-08       Impact factor: 6.167

Review 6.  Calcineurin signaling as a target for the treatment of alcohol abuse and neuroinflammatory disorders.

Authors:  Patrick J Ronan; Sarah A Flynn; Thomas P Beresford
Journal:  Prog Mol Biol Transl Sci       Date:  2019-08-12       Impact factor: 3.622

7.  Exploring blood-brain barrier hyperpermeability and potential biomarkers in traumatic brain injury.

Authors:  Bobby Darnell Robinson; Binu Tharakan; Angela Lomas; Katie Wiggins-Dohlvik; Himakarnika Alluri; Chinchusha Anasooya Shaji; Daniel Jupiter; Claire Larson Isbell
Journal:  Proc (Bayl Univ Med Cent)       Date:  2020-04-02

8.  New Wavelet Neurovascular Bundle for Bedside Evaluation of Cerebral Autoregulation and Neurovascular Coupling in Newborns with Hypoxic-Ischemic Encephalopathy.

Authors:  Lina F Chalak; Rong Zhang
Journal:  Dev Neurosci       Date:  2017-03-30       Impact factor: 2.984

9.  Enzymatic protection and biocompatibility screening of enzyme-loaded polymeric nanoparticles for neurotherapeutic applications.

Authors:  Rick Liao; Jessica Pon; Michael Chungyoun; Elizabeth Nance
Journal:  Biomaterials       Date:  2020-07-15       Impact factor: 12.479

10.  Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury.

Authors:  Edward J Goetzl; Fanny M Elahi; Maja Mustapic; Dimitrios Kapogiannis; Moira Pryhoda; Anah Gilmore; Kimberly A Gorgens; Bradley Davidson; Anne-Charlotte Granholm; Aurélie Ledreux
Journal:  FASEB J       Date:  2019-01-03       Impact factor: 5.191
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