| Literature DB >> 27521108 |
Abstract
Immune checkpoint inhibitors are a class of drugs that utilizes immunotherapy to target various cancers. Included are the anti-CTLA-4 and anti-PD-1 receptor antibodies. By reprogramming the immune system, these agents provide a therapy that destroys cancer cells. However, this approach runs the risk of allowing pathologic autoimmunity and organ injury to develop. Unsurprisingly, immune-related adverse effects are described including pneumonitis, colitis, and various endocrinopathies. Now added to this list is AKI, primarily due to ATIN.Entities:
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Year: 2016 PMID: 27521108 DOI: 10.1016/j.kint.2016.05.024
Source DB: PubMed Journal: Kidney Int ISSN: 0085-2538 Impact factor: 10.612