Literature DB >> 27520943

Emerging therapeutics for the treatment of diabetic nephropathy.

Jehrod Brenneman1, Jon Hill2, Steve Pullen3.   

Abstract

Diabetic nephropathy (DN) is the most common pathology contributing to the development of chronic kidney disease (CKD). DN caused by hypertension and unmitigated inflammation in diabetics, renders the kidneys unable to perform normally, and leads to renal fibrosis and organ failure. The increasing global prevalence of DN has been directly attributed to rising incidences of Type II diabetes, and is now the largest non-communicable cause of death worldwide. Despite the high morbidity, successful new treatments for DN are lacking. This review seeks to provide new insight on emerging clinical candidates under investigation for the treatment of DN.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Diabetic nephropathy; Fibrosis; Inflammation; Kidney disease; Therapeutics

Mesh：

Year:  2016        PMID： 27520943     DOI： 10.1016/j.bmcl.2016.07.079

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  Histone demethylase UTX is a therapeutic target for diabetic kidney disease.

Authors:  Hong Chen; Yixue Huang; Xiuqin Zhu; Chong Liu; Yangmian Yuan; Hua Su; Chun Zhang; Chengyu Liu; Mingrui Xiong; Yannan Qu; Peng Yun; Ling Zheng; Kun Huang
Journal:  J Physiol       Date:  2018-12-25       Impact factor: 5.182

2.  The glycocalyx, a novel key in understanding of mechanism of diabetic nephropathy: a commentary.

Authors:  Behnam Amirpour-Najafabadi; Seyed-Sirvan Hosseini; Parnian Sam-Sani; Erfan Rezaei; Majid Ramezani; Saeed Changizi-Ashtiyani
Journal:  J Diabetes Metab Disord       Date:  2021-06-26

3.  A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes.

Authors:  Md Abdul Hye Khan; Lauren Kolb; Melissa Skibba; Markus Hartmann; René Blöcher; Ewgenij Proschak; John D Imig
Journal:  Diabetologia       Date:  2018-07-21       Impact factor: 10.122

Review 4.  Mechanistic Insight and Management of Diabetic Nephropathy: Recent Progress and Future Perspective.

Authors:  Rui Xue; Dingkun Gui; Liyang Zheng; Ruonan Zhai; Feng Wang; Niansong Wang
Journal:  J Diabetes Res       Date:  2017-03-13       Impact factor: 4.011

5.  The Effects of Salvianolate Combined With Western Medicine on Diabetic Nephropathy: A Systematic Review and Meta-Analysis.

Authors:  Yuehong Shen; Shulin Wang; Yuanyuan Liu; Ling Ge; Lili Xia; Xiaoxiao Zhang; Yuying Miao; Jianping Shen; Qian Zhou
Journal:  Front Pharmacol       Date:  2020-06-12       Impact factor: 5.810

Review 6.  Comparing the Efficacy of Angiotensin Converting Enzyme Inhibitors with Calcium Channel Blockers on the Treatment of Diabetic Nephropathy: A Meta-Analysis.

Authors:  Zhaowei Zhang; Chunlin Chen; Shiwen Lv; Yalan Zhu; Tianzi Fang
Journal:  Iran J Public Health       Date:  2019-02       Impact factor: 1.429

7.  A Nucleoside/Nucleobase-Rich Extract from Cordyceps Sinensis Inhibits the Epithelial-Mesenchymal Transition and Protects against Renal Fibrosis in Diabetic Nephropathy.

Authors:  Zhonghua Dong; Yueyue Sun; Guangwei Wei; Siying Li; Zhongxi Zhao
Journal:  Molecules       Date:  2019-11-14       Impact factor: 4.411

8.  Anti-Diabetic Nephropathy Activities of Polysaccharides Obtained from Termitornyces albuminosus via Regulation of NF-κB Signaling in db/db Mice.

Authors:  Chang Yang; Qi Feng; Huan Liao; Xinlei Yu; Yang Liu; Di Wang
Journal:  Int J Mol Sci       Date:  2019-10-21       Impact factor: 5.923

9.  Bioinformatics Analysis Reveals Crosstalk Among Platelets, Immune Cells, and the Glomerulus That May Play an Important Role in the Development of Diabetic Nephropathy.

Authors:  Xinyue Yao; Hong Shen; Fukai Cao; Hailan He; Boyu Li; Haojun Zhang; Xinduo Zhang; Zhiguo Li
Journal:  Front Med (Lausanne)       Date:  2021-06-24

10.  Lovastatin Alleviates Endothelial-to-Mesenchymal Transition in Glomeruli via Suppression of Oxidative Stress and TGF-β1 Signaling.

Authors:  Zejun Ma; Lili Zhu; Yan Liu; Zhida Wang; Yang Yang; Liming Chen; Qiulun Lu
Journal:  Front Pharmacol       Date:  2017-07-18       Impact factor: 5.810
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