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Literature DB >> 27520107

Effect of catecholamines and β-blockers on linoleic acid desaturation activity.

I N de Gómez Dumm¹, M J de Alaniz¹, R R Brenner¹.

Abstract

The effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-(14)C]linoleic acid to γ-linolenic acid. The effect of epinephrine was blocked by single injections of the β blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment. Isoproterenol (100 μg/kg body weight) produced a significant decrease on the activity of the linoleyl-CoA desaturase. The effect of the catecholamines was postulated to be mediated through β receptors by an enhancement of the intracellular levels of cyclic AMP.

Entities: Chemical Species

Year: 1978 PMID： 27520107 DOI： 10.1007/BF02533740

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

18 in total

1. THE EFFECTS OF ADRENERGIC BLOCKING AGENTS AND THEOPHYLLINE ON 3',5'-AMP-INDUCED HYPERGLYCEMIA.

Authors: G NORTHROP; R E PARKS
Journal: J Pharmacol Exp Ther Date: 1964-07 Impact factor: 4.030

2. An o-toluidine method for body-fluid glucose determination.

Authors: K M DUBOWSKI
Journal: Clin Chem Date: 1962 May-Jun Impact factor: 8.327

3. Effects of glucagon and dibutyryl adenosine 3', 5'-cyclic monophosphate on oxidative desaturation of fatty acids in the rat.

Authors: I N de Gómez Dumm; M J de Alaniz; R R Brenner
Journal: J Lipid Res Date: 1975-07 Impact factor: 5.922

4. Determination of serum proteins by means of the biuret reaction.

Authors: A G GORNALL; C J BARDAWILL; M M DAVID
Journal: J Biol Chem Date: 1949-02 Impact factor: 5.157

5. The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat.

Authors: G H Evans; A S Nies; D G Shand
Journal: J Pharmacol Exp Ther Date: 1973-07 Impact factor: 4.030

6. Effects of adrenergic agents on carbohydrate metabolism of rat liver: activities of adenyl cyclase and glycogen phosphorylase.

Authors: N E Newton; K R Hornbrook
Journal: J Pharmacol Exp Ther Date: 1972-06 Impact factor: 4.030

7. Effect of propranolol on the blockade of alpha adrenergic receptors.

Authors: H I Yamamura; A Horita
Journal: J Pharmacol Exp Ther Date: 1968-11 Impact factor: 4.030

8. Effect of epinephrine on the oxidative desaturation of fatty acids in the rat.

Authors: N T de Gómez Dumm; M J de Alaniz; R R Brenner
Journal: J Lipid Res Date: 1976-11 Impact factor: 5.922

9. Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic, and linolenic acids.

Authors: R R Brenner; R O Peluffo
Journal: J Biol Chem Date: 1966-11-25 Impact factor: 5.157

10. Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions.

Authors: J C Castuma; A Catala; R R Brenner
Journal: J Lipid Res Date: 1972-11 Impact factor: 5.922

7 in total

Effect of catecholamines and β-blockers on linoleic acid desaturation activity.

1. THE EFFECTS OF ADRENERGIC BLOCKING AGENTS AND THEOPHYLLINE ON 3',5'-AMP-INDUCED HYPERGLYCEMIA.

2. An o-toluidine method for body-fluid glucose determination.

3. Effects of glucagon and dibutyryl adenosine 3', 5'-cyclic monophosphate on oxidative desaturation of fatty acids in the rat.

4. Determination of serum proteins by means of the biuret reaction.

5. The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat.

6. Effects of adrenergic agents on carbohydrate metabolism of rat liver: activities of adenyl cyclase and glycogen phosphorylase.

7. Effect of propranolol on the blockade of alpha adrenergic receptors.

8. Effect of epinephrine on the oxidative desaturation of fatty acids in the rat.

9. Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic, and linolenic acids.

10. Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions.

1. Effect of magnesium deficiency on delta 6 desaturase activity and fatty acid composition of rat liver microsomes.

2. Dexamethasone blocks arachidonate biosynthesis in isolated hepatocytes and cultured hepatoma cells.

3. Effect of epinephrine on the oxidative desaturation of fatty acids in the rat adrenal gland.

4. Effect of various steroids on the biosynthesis of arachidonic acid in isolated hepatocytes and HTC cells.

5. Effects of essential fatty acid administration on cardiovascular responses to stress in the rat.

6. Gamma linolenic acid attenuates cardiovascular responses to stress in borderline hypertensive rats.

7. Effect of epinephrine and dibutyryl cyclic AMP on delta 5-desaturation activity of rat liver microsomes.