| Literature DB >> 27519625 |
Lihong Guan1, Yawei Han2, Shaoyi Zhu3, Juntang Lin4.
Abstract
The clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated proteins (Cas) belong to the crucial adaptive immune system, which exist in archaea and bacteria. Currently, CRISPR-Cas9 system has been modified and widely used to edit genome. In this review, we summarized the discovery, classification and mechanism of CRISPR-Cas system and further discussed the application of CRISPR-Cas9 in gene therapy, mainly in disease models.Keywords: CRISPR-Cas9; DNA repair; Disease model; Gene therapy; Genome editing
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Year: 2016 PMID： 27519625 DOI： 10.1016/j.dnarep.2016.07.004
Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856