Literature DB >> 27519133

Brown and Beige Adipose Tissue: Therapy for Obesity and Its Comorbidities?

Anny Mulya1, John P Kirwan2.   

Abstract

Overweight and obesity are global health problems placing an ever-increasing demand on health care systems. Brown adipose tissue (BAT) is present in significant amounts in adults. BAT has potential as a fuel for oxidation and dissipation as heat production, which makes it an attractive target for obesity therapy. BAT activation results in increased energy expenditure via thermogenesis. The role of BAT/beige adipocyte activation on whole body energy homeostasis, body weight management/regulation, and whole body glucose and lipid homeostasis remains unproven. This paper reviews knowledge on brown/beige adipocytes in energy expenditure and how it may impact obesity therapy and its comorbidities.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Beige adipose tissue; Brown adipose tissue; Energy expenditure; Lifestyle intervention; Obesity; Thermogenesis; Type 2 diabetes

Mesh：

Year:  2016        PMID： 27519133      PMCID： PMC5206678          DOI： 10.1016/j.ecl.2016.04.010

Source DB:  PubMed          Journal:  Endocrinol Metab Clin North Am        ISSN： 0889-8529            Impact factor:   4.741


  118 in total

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Authors:  Roberto Justo; Jordi Oliver; Magdalena Gianotti
Journal:  Mitochondrion       Date:  2005-02       Impact factor: 4.160

2.  Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

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Journal:  Cell       Date:  2014-06-05       Impact factor: 41.582

3.  IL-6 selectively stimulates fat metabolism in human skeletal muscle.

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Journal:  Am J Physiol Endocrinol Metab       Date:  2010-09-07       Impact factor: 4.310

4.  FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

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Journal:  N Engl J Med       Date:  2015-08-19       Impact factor: 91.245

5.  Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria.

Authors:  Andriy Fedorenko; Polina V Lishko; Yuriy Kirichok
Journal:  Cell       Date:  2012-10-12       Impact factor: 41.582

6.  Cold acclimation recruits human brown fat and increases nonshivering thermogenesis.

Authors:  Anouk A J J van der Lans; Joris Hoeks; Boudewijn Brans; Guy H E J Vijgen; Mariëlle G W Visser; Maarten J Vosselman; Jan Hansen; Johanna A Jörgensen; Jun Wu; Felix M Mottaghy; Patrick Schrauwen; Wouter D van Marken Lichtenbelt
Journal:  J Clin Invest       Date:  2013-07-15       Impact factor: 14.808

7.  Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.

Authors:  Ruidan Xue; Matthew D Lynes; Jonathan M Dreyfuss; Farnaz Shamsi; Tim J Schulz; Hongbin Zhang; Tian Lian Huang; Kristy L Townsend; Yiming Li; Hirokazu Takahashi; Lauren S Weiner; Andrew P White; Maureen S Lynes; Lee L Rubin; Laurie J Goodyear; Aaron M Cypess; Yu-Hua Tseng
Journal:  Nat Med       Date:  2015-06-15       Impact factor: 53.440

8.  A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis.

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Journal:  Diabetes       Date:  2015-01-20       Impact factor: 9.461

9.  Dietary fat overload reprograms brown fat mitochondria.

Authors:  Daniele Lettieri Barbato; Giuseppe Tatulli; Rolando Vegliante; Stefano M Cannata; Sergio Bernardini; Maria R Ciriolo; Katia Aquilano
Journal:  Front Physiol       Date:  2015-09-29       Impact factor: 4.566

10.  FNDC5/irisin is not only a myokine but also an adipokine.

Authors:  Arturo Roca-Rivada; Cecilia Castelao; Lucía L Senin; María O Landrove; Javier Baltar; Ana Belén Crujeiras; Luisa María Seoane; Felipe F Casanueva; María Pardo
Journal:  PLoS One       Date:  2013-04-11       Impact factor: 3.240
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  14 in total

1.  No evidence of white adipocyte browning after endurance exercise training in obese men.

Authors:  T Tsiloulis; A L Carey; J Bayliss; B Canny; R C R Meex; M J Watt
Journal:  Int J Obes (Lond)       Date:  2017-11-30       Impact factor: 5.095

2.  Identification of a natural beige adipose depot in mice.

Authors:  Michelle Chan; Yen Ching Lim; Jing Yang; Maria Namwanje; Longhua Liu; Li Qiang
Journal:  J Biol Chem       Date:  2019-03-01       Impact factor: 5.157

Review 3.  Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis.

Authors:  Meshail Okla; Jiyoung Kim; Karsten Koehler; Soonkyu Chung
Journal:  Adv Nutr       Date:  2017-05-15       Impact factor: 8.701

4.  Lytic cocktail: An effective method to alleviate severe burn induced hyper-metabolism through regulating white adipose tissue browning.

Authors:  Meng Zhang; Peilang Yang; Tianyi Yu; Martin C Harmsen; Min Gao; Dan Liu; Yan Shi; Yan Liu; Xiong Zhang
Journal:  Heliyon       Date:  2022-03-17

5.  Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions.

Authors:  Francisca M Acosta; Katerina Stojkova; Jingruo Zhang; Eric Ivan Garcia Huitron; Jean X Jiang; Christopher R Rathbone; Eric M Brey
Journal:  J Tissue Eng       Date:  2022-06-24       Impact factor: 7.940

Review 6.  Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging.

Authors:  Maria De Luca; Maurizio Mandala; Giuseppina Rose
Journal:  Mech Ageing Dev       Date:  2021-06-18       Impact factor: 5.498

7.  Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation.

Authors:  Xiaozhao Lu; Danna Bai; Xiangwei Liu; Chen Zhou; Guodong Yang
Journal:  Sci Rep       Date:  2017-03-31       Impact factor: 4.379

8.  Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis-associated cachexia.

Authors:  Wai W Cheung; Sheng Hao; Zhen Wang; Wei Ding; Ronghao Zheng; Alex Gonzalez; Jian-Ying Zhan; Ping Zhou; Shiping Li; Mary C Esparza; Hal M Hoffman; Richard L Lieber; Robert H Mak
Journal:  J Cachexia Sarcopenia Muscle       Date:  2019-11-13       Impact factor: 12.910

Review 9.  Nanotechnology advances towards development of targeted-treatment for obesity.

Authors:  Nicole Remaliah Samantha Sibuyi; Koena Leah Moabelo; Mervin Meyer; Martin Opiyo Onani; Admire Dube; Abram Madimabe Madiehe
Journal:  J Nanobiotechnology       Date:  2019-12-16       Impact factor: 10.435

10.  Exercise and/or Cold Exposure Alters the Gene Expression Profile in the Fat Body and Changes the Heart Function in Drosophila.

Authors:  Ting Huang; Xiaoyi Jian; Jinglin Liu; Lan Zheng; Fang Qiu Li; Ding Meng; Tongquan Wang; Shihu Zhang; Yi Liu; Zhilong Guan; Jiadong Feng
Journal:  Front Endocrinol (Lausanne)       Date:  2022-03-28       Impact factor: 6.055
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