Literature DB >> 27519002

Erroneous plasma "cortisol" values in Addison's disease : A problem of the fluorimetric assay of 11-OH corticosteroids.

G MacFlynn1,2,3, G D Johnston1,2,3, D G McDevitt1,2,3, D R Hadden1,2,3.   

Abstract

A case is described in which a woman, being investigated for Addison's disease, had what appeared initially to be plasma cortisol levels within the normal range. Subsequent investigations including ACTH stimulation and an immunofluorescent test for adrenal cortical antibodies showed the diagnosis to be correct. Attention is drawn to the lack of specificity of the fluorimetric plasma 11-OH corticosteroid assay and, therefore, to the danger of using plasma "cortisol" as a screening test for adrenocortical hypofunction.

Entities:  

Year:  1975        PMID: 27519002     DOI: 10.1007/BF02939058

Source DB:  PubMed          Journal:  Ir J Med Sci        ISSN: 0021-1265            Impact factor:   1.568


  3 in total

1.  A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.

Authors:  D MATTINGLY
Journal:  J Clin Pathol       Date:  1962-07       Impact factor: 3.411

2.  Steroid excretion and plasma cortisol in 41 cases of Cushing's syndrome. With data on corticotrophin and metapyron tests.

Authors:  I Ernest
Journal:  Acta Endocrinol (Copenh)       Date:  1966-04

3.  Simple screening test for Cushing's syndrome.

Authors:  D Mattingly; C Tyler
Journal:  Br Med J       Date:  1967-11-18
  3 in total

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