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Literature DB >> 27518980

The free cortisol index.

Abstract

The development of the Free Cortisol Index, an indirect measurement of the free or metabolically active portion of circulating cortisol, is described. Patients with non-adrenal disease had FCl values in the same range as normal subjects and in patients with adrenal disease the FCl values moved in the same direction as the total plasma cortisol. FCl values exhibited the same diurnal variation and response to ACTH as did total plasma cortisol in normal subjects. In pregnancy a significant rise in FCl was found confirming previous evidence of a degree of hyperadrenocorticalism in this condition.

Entities: Chemical Disease Gene Species

Year: 1975 PMID： 27518980 DOI： 10.1007/BF02939036

Source DB: PubMed Journal: Ir J Med Sci ISSN： 0021-1265 Impact factor: 1.568

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References

14 in total

1. DETERMINATION OF THE BINDING CAPACITY OF CORTICOSTEROID-BINDING GLOBULIN BY PAPER ELECTROPHORESIS.

Authors: C OSORIO; D L SCHATS
Journal: J Clin Endocrinol Metab Date: 1964-10 Impact factor: 5.958

2. MEASUREMENT OF CORTICOSTEROID-BINDING GLOBULIN IN MAN.

Authors: R P DOE; R FERNANDEZ; U S SEAL
Journal: J Clin Endocrinol Metab Date: 1964-10 Impact factor: 5.958

3. ASSESSMENT OF THYROID FUNCTION BY THE COMBINED USE OF THE SERUM PROTEIN-BOUND IODINE AND RESIN UPTAKE OF 131-I-TRIIODOTHYRONINE.

Authors: F CLARK; D B HORN
Journal: J Clin Endocrinol Metab Date: 1965-01 Impact factor: 5.958

10. Comparison of thyroid function in each trimester of pregnancy with the use of triiodothyronine uptake, thyroxine iodine, free thyroxine, and free thyroxine index.

Authors: J A Souma; D C Niejadlik; S Cottrell; S Rankel
Journal: Am J Obstet Gynecol Date: 1973-08-01 Impact factor: 8.661

The free cortisol index.

1. DETERMINATION OF THE BINDING CAPACITY OF CORTICOSTEROID-BINDING GLOBULIN BY PAPER ELECTROPHORESIS.

2. MEASUREMENT OF CORTICOSTEROID-BINDING GLOBULIN IN MAN.

3. ASSESSMENT OF THYROID FUNCTION BY THE COMBINED USE OF THE SERUM PROTEIN-BOUND IODINE AND RESIN UPTAKE OF 131-I-TRIIODOTHYRONINE.

4. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.

5. Studies on some parameters of adrenocortical function.

6. Clinical evaluation of urinary cortisol determinations by competetive protein-binding radioassay.

7. Determination of blood corticoids using the in vitro resin uptake of 3H-prednisolone.

8. Plasma cortisol-binding capacity in mental illness.

9. Accurate measurement of steroid-protein binding by steady-state gel filtration.

10. Comparison of thyroid function in each trimester of pregnancy with the use of triiodothyronine uptake, thyroxine iodine, free thyroxine, and free thyroxine index.