Daniel Munblit1, Valérie Verhasselt. 1. aDepartment of Paediatrics, Imperial College London, UK bInternational Inflammation Network (in-FLAME) of the World Universities Network, Perth, Australia cEA 6302 University Nice Sophia-Antipolis, TIM, Nice, France dFaculty of Pediatrics, I. M. Sechenov First Moscow State Medical University, Russia eChair of Human Lactology, School of Chemistry and Biochemistry, University of Western Australia, Perth, Australia.
Abstract
PURPOSE OF REVIEW: Allergy is a modern disease which does not seem to benefit from breast milk preventive effects. We propose that maternal milk composition has not adapted to the needs of allergy prevention because of the recent and rapid increase of allergy. Modulation of breast milk composition may be the best strategy to counteract allergy development. We will review recent advances in understanding of allergy physiopathology and how breast milk factors may be specifically appropriate to interfere with allergy development in early life. RECENT FINDINGS: There is strong evidence both from rodent and human studies that breast milk factors may impact on parameters which are now recognized to be essential for allergy physiopathology: infant gut barrier function, microbiota metabolites production, and oral tolerance induction. Data from human cohorts support the possibility to modify breast milk composition by selected interventions and to impact health outcomes in offspring. SUMMARY: Nutritional intervention in lactating mothers should endow breast milk with the capacity to combat allergy epidemics in addition to infectious disease.
PURPOSE OF REVIEW: Allergy is a modern disease which does not seem to benefit from breast milk preventive effects. We propose that maternal milk composition has not adapted to the needs of allergy prevention because of the recent and rapid increase of allergy. Modulation of breast milk composition may be the best strategy to counteract allergy development. We will review recent advances in understanding of allergy physiopathology and how breast milk factors may be specifically appropriate to interfere with allergy development in early life. RECENT FINDINGS: There is strong evidence both from rodent and human studies that breast milk factors may impact on parameters which are now recognized to be essential for allergy physiopathology: infant gut barrier function, microbiota metabolites production, and oral tolerance induction. Data from human cohorts support the possibility to modify breast milk composition by selected interventions and to impact health outcomes in offspring. SUMMARY: Nutritional intervention in lactating mothers should endow breast milk with the capacity to combat allergy epidemics in addition to infectious disease.
Authors: Fernanda Rosa; Ashok K Sharma; Manoj Gurung; David Casero; Katelin Matazel; Lars Bode; Christy Simecka; Ahmed A Elolimy; Patricia Tripp; Christopher Randolph; Timothy W Hand; Keith D Williams; Tanya LeRoith; Laxmi Yeruva Journal: Front Immunol Date: 2022-06-29 Impact factor: 8.786
Authors: Daniel Munblit; Diego G Peroni; Alba Boix-Amorós; Peter S Hsu; Belinda Van't Land; Melvin C L Gay; Anastasia Kolotilina; Chrysanthi Skevaki; Robert J Boyle; Maria Carmen Collado; Johan Garssen; Donna T Geddes; Ralph Nanan; Carolyn Slupsky; Ganesa Wegienka; Anita L Kozyrskyj; John O Warner Journal: Nutrients Date: 2017-08-17 Impact factor: 5.717
Authors: Daniel Munblit; Marina Treneva; Diego G Peroni; Silvia Colicino; Li Yan Chow; Shobana Dissanayeke; Alexander Pampura; Attilio L Boner; Donna T Geddes; Robert J Boyle; John O Warner Journal: Nutrients Date: 2017-05-24 Impact factor: 5.717