Literature DB >> 27518554

Bile Acid Analog Intercepts Liver Fibrosis.

C Daniel De Magalhaes Filho1, Michael Downes1, Ron Evans2.   

Abstract

Ocaliva, a synthetic bile acid analog with high affinity for the nuclear bile acid receptor FXR, is effective in treating primary biliary cholangitis, an autoimmune liver disease. It works in patients who fail to respond to or cannot tolerate conventional treatment with the natural bile acid ursodeoxycholic acid (UDCA).
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Year:  2016        PMID： 27518554     DOI： 10.1016/j.cell.2016.08.001

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  9 in total

Review 1.  Microbial modulation of cardiovascular disease.

Authors:  J Mark Brown; Stanley L Hazen
Journal:  Nat Rev Microbiol       Date:  2018-01-08       Impact factor: 60.633

2.  Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis.

Authors:  Sangwon Byun; Hyunkyung Jung; Jinjing Chen; Young-Chae Kim; Dong-Hyun Kim; Bo Kong; Grace Guo; Byron Kemper; Jongsook Kim Kemper
Journal:  J Biol Chem       Date:  2019-04-17       Impact factor: 5.157

3.  Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells.

Authors:  Zili Zhang; Zhen Yao; Ling Wang; Hai Ding; Jiangjuan Shao; Anping Chen; Feng Zhang; Shizhong Zheng
Journal:  Autophagy       Date:  2018-08-21       Impact factor: 16.016

Review 4.  Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis.

Authors:  Wei Jia; Guoxiang Xie; Weiping Jia
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2017-10-11       Impact factor: 46.802

5.  RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.

Authors:  Zili Zhang; Mei Guo; Yujia Li; Min Shen; Desong Kong; Jiangjuan Shao; Hai Ding; Shanzhong Tan; Anping Chen; Feng Zhang; Shizhong Zheng
Journal:  Autophagy       Date:  2019-11-11       Impact factor: 16.016

6.  Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases.

Authors:  Ibrahim Choucair; Ina Nemet; Lin Li; Margaret A Cole; Sarah M Skye; Jennifer D Kirsop; Michael A Fischbach; Valentin Gogonea; J Mark Brown; W H Wilson Tang; Stanley L Hazen
Journal:  J Lipid Res       Date:  2019-12-09       Impact factor: 5.922

7.  Bile Acids Elevated in Chronic Periaortitis Could Activate Farnesoid-X-Receptor to Suppress IL-6 Production by Macrophages.

Authors:  Shan Cao; Xinyu Meng; Yixuan Li; Li Sun; Lindi Jiang; Hanqing Xuan; Xiaoxiang Chen
Journal:  Front Immunol       Date:  2021-04-22       Impact factor: 7.561

8.  SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis.

Authors:  Jiyu Zhou; Shuang Cui; Qingxian He; Yitong Guo; Xiaojie Pan; Pengfei Zhang; Ningning Huang; Chaoliang Ge; Guangji Wang; Frank J Gonzalez; Hong Wang; Haiping Hao
Journal:  Nat Commun       Date:  2020-01-13       Impact factor: 14.919

9.  Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis.

Authors:  Sangwon Byun; Dong-Hyun Kim; Daniel Ryerson; Young-Chae Kim; Hao Sun; Bo Kong; Peter Yau; Grace Guo; H Eric Xu; Byron Kemper; Jongsook Kim Kemper
Journal:  Nat Commun       Date:  2018-07-03       Impact factor: 14.919
  9 in total

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