Literature DB >> 27516171

Open data in drug discovery and development: lessons from malaria.

Timothy N C Wells1, Paul Willis1, Jeremy N Burrows1, Rob Hooft van Huijsduijnen1.   

Abstract

There is a growing consensus that drug discovery thrives in an open environment. Here, we describe how the malaria community has embraced four levels of open data - open science, open innovation, open access and open source - to catalyse the development of new medicines, and consider principles that could enable open data approaches to be applied to other disease areas.

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Year:  2016        PMID： 27516171     DOI： 10.1038/nrd.2016.154

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  5 in total

1.  Cancer research: Open ambition.

Authors:  Amy Maxmen
Journal:  Nature       Date:  2012-08-09       Impact factor: 49.962

2.  Thousands of chemical starting points for antimalarial lead identification.

Authors:  Francisco-Javier Gamo; Laura M Sanz; Jaume Vidal; Cristina de Cozar; Emilio Alvarez; Jose-Luis Lavandera; Dana E Vanderwall; Darren V S Green; Vinod Kumar; Samiul Hasan; James R Brown; Catherine E Peishoff; Lon R Cardon; Jose F Garcia-Bustos
Journal:  Nature       Date:  2010-05-20       Impact factor: 49.962

3.  The successes and challenges of open-source biopharmaceutical innovation.

Authors:  Minna Allarakhia
Journal:  Expert Opin Drug Discov       Date:  2014-04-05       Impact factor: 6.098

4.  The Economics of Reproducibility in Preclinical Research.

Authors:  Leonard P Freedman; Iain M Cockburn; Timothy S Simcoe
Journal:  PLoS Biol       Date:  2015-06-09       Impact factor: 8.029

5.  Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:  Wesley C Van Voorhis; John H Adams; Roberto Adelfio; Vida Ahyong; Myles H Akabas; Pietro Alano; Aintzane Alday; Yesmalie Alemán Resto; Aishah Alsibaee; Ainhoa Alzualde; Katherine T Andrews; Simon V Avery; Vicky M Avery; Lawrence Ayong; Mark Baker; Stephen Baker; Choukri Ben Mamoun; Sangeeta Bhatia; Quentin Bickle; Lotfi Bounaadja; Tana Bowling; Jürgen Bosch; Lauren E Boucher; Fabrice F Boyom; Jose Brea; Marian Brennan; Audrey Burton; Conor R Caffrey; Grazia Camarda; Manuela Carrasquilla; Dee Carter; Maria Belen Cassera; Ken Chih-Chien Cheng; Worathad Chindaudomsate; Anthony Chubb; Beatrice L Colon; Daisy D Colón-López; Yolanda Corbett; Gregory J Crowther; Noemi Cowan; Sarah D'Alessandro; Na Le Dang; Michael Delves; Joseph L DeRisi; Alan Y Du; Sandra Duffy; Shimaa Abd El-Salam El-Sayed; Michael T Ferdig; José A Fernández Robledo; David A Fidock; Isabelle Florent; Patrick V T Fokou; Ani Galstian; Francisco Javier Gamo; Suzanne Gokool; Ben Gold; Todd Golub; Gregory M Goldgof; Rajarshi Guha; W Armand Guiguemde; Nil Gural; R Kiplin Guy; Michael A E Hansen; Kirsten K Hanson; Andrew Hemphill; Rob Hooft van Huijsduijnen; Takaaki Horii; Paul Horrocks; Tyler B Hughes; Christopher Huston; Ikuo Igarashi; Katrin Ingram-Sieber; Maurice A Itoe; Ajit Jadhav; Amornrat Naranuntarat Jensen; Laran T Jensen; Rays H Y Jiang; Annette Kaiser; Jennifer Keiser; Thomas Ketas; Sebastien Kicka; Sunyoung Kim; Kiaran Kirk; Vidya P Kumar; Dennis E Kyle; Maria Jose Lafuente; Scott Landfear; Nathan Lee; Sukjun Lee; Adele M Lehane; Fengwu Li; David Little; Liqiong Liu; Manuel Llinás; Maria I Loza; Aristea Lubar; Leonardo Lucantoni; Isabelle Lucet; Louis Maes; Dalu Mancama; Nuha R Mansour; Sandra March; Sheena McGowan; Iset Medina Vera; Stephan Meister; Luke Mercer; Jordi Mestres; Alvine N Mfopa; Raj N Misra; Seunghyun Moon; John P Moore; Francielly Morais Rodrigues da Costa; Joachim Müller; Arantza Muriana; Stephen Nakazawa Hewitt; Bakela Nare; Carl Nathan; Nathalie Narraidoo; Sujeevi Nawaratna; Kayode K Ojo; Diana Ortiz; Gordana Panic; George Papadatos; Silvia Parapini; Kailash Patra; Ngoc Pham; Sarah Prats; David M Plouffe; Sally-Ann Poulsen; Anupam Pradhan; Celia Quevedo; Ronald J Quinn; Christopher A Rice; Mohamed Abdo Rizk; Andrea Ruecker; Robert St Onge; Rafaela Salgado Ferreira; Jasmeet Samra; Natalie G Robinett; Ulrich Schlecht; Marjorie Schmitt; Filipe Silva Villela; Francesco Silvestrini; Robert Sinden; Dennis A Smith; Thierry Soldati; Andreas Spitzmüller; Serge Maximilian Stamm; David J Sullivan; William Sullivan; Sundari Suresh; Brian M Suzuki; Yo Suzuki; S Joshua Swamidass; Donatella Taramelli; Lauve R Y Tchokouaha; Anjo Theron; David Thomas; Kathryn F Tonissen; Simon Townson; Abhai K Tripathi; Valentin Trofimov; Kenneth O Udenze; Imran Ullah; Cindy Vallieres; Edgar Vigil; Joseph M Vinetz; Phat Voong Vinh; Hoan Vu; Nao-Aki Watanabe; Kate Weatherby; Pamela M White; Andrew F Wilks; Elizabeth A Winzeler; Edward Wojcik; Melanie Wree; Wesley Wu; Naoaki Yokoyama; Paul H A Zollo; Nada Abla; Benjamin Blasco; Jeremy Burrows; Benoît Laleu; Didier Leroy; Thomas Spangenberg; Timothy Wells; Paul A Willis
Journal:  PLoS Pathog       Date:  2016-07-28       Impact factor: 6.823
  5 in total
  9 in total

1.  Managing intellectual property to develop medicines for the world's poorest.

Authors:  Sylvie Fonteilles-Drabek; David Reddy; Timothy N C Wells
Journal:  Nat Rev Drug Discov       Date:  2017-02-24       Impact factor: 84.694

2.  Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.

Authors:  Sandra Duffy; Melissa L Sykes; Amy J Jones; Todd B Shelper; Moana Simpson; Rebecca Lang; Sally-Ann Poulsen; Brad E Sleebs; Vicky M Avery
Journal:  Antimicrob Agents Chemother       Date:  2017-08-24       Impact factor: 5.191

3.  Towards a systems approach for chronic diseases, based on health state modeling.

Authors:  Michael Rebhan
Journal:  F1000Res       Date:  2017-03-23

4.  Systematically linking tranSMART, Galaxy and EGA for reusing human translational research data.

Authors:  Chao Zhang; Jochem Bijlard; Christine Staiger; Serena Scollen; David van Enckevort; Youri Hoogstrate; Alexander Senf; Saskia Hiltemann; Susanna Repo; Wibo Pipping; Mariska Bierkens; Stefan Payralbe; Bas Stringer; Jaap Heringa; Andrew Stubbs; Luiz Olavo Bonino Da Silva Santos; Jeroen Belien; Ward Weistra; Rita Azevedo; Kees van Bochove; Gerrit Meijer; Jan-Willem Boiten; Jordi Rambla; Remond Fijneman; J Dylan Spalding; Sanne Abeln
Journal:  F1000Res       Date:  2017-08-16

Review 5.  Drugs in Development for Malaria.

Authors:  Elizabeth A Ashley; Aung Pyae Phyo
Journal:  Drugs       Date:  2018-06       Impact factor: 9.546

6.  Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis.

Authors:  Reto Rufener; Luca Dick; Laura D'Ascoli; Dominic Ritler; Amani Hizem; Timothy N C Wells; Andrew Hemphill; Britta Lundström-Stadelmann
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2018-10-31       Impact factor: 4.077

Review 7.  Actives from MMV Open Access Boxes? A suggested way forward.

Authors:  Kirandeep Samby; Paul A Willis; Jeremy N Burrows; Benoît Laleu; Peter J H Webborn
Journal:  PLoS Pathog       Date:  2021-04-22       Impact factor: 6.823

8.  The Pandemic Response Box─Accelerating Drug Discovery Efforts after Disease Outbreaks.

Authors:  Kirandeep Samby; Dominique Besson; Anirban Dutta; Buddhadev Patra; Angelique Doy; Paul Glossop; James Mills; Gavin Whitlock; Rob Hooft van Huijsduijnen; Alessandra Monaco; Graeme Bilbe; Charles Mowbray; Benjamin Perry; Anna Adam; Timothy N C Wells; Paul A Willis
Journal:  ACS Infect Dis       Date:  2022-03-14       Impact factor: 5.084

9.  Developing international open science collaborations: Funder reflections on the Open Science Prize.

Authors:  Elizabeth Kittrie; Audie A Atienza; Robert Kiley; David Carr; Aki MacFarlane; Vinay Pai; Jennifer Couch; Jared Bajkowski; Joseph F Bonner; Daniel Mietchen; Philip E Bourne
Journal:  PLoS Biol       Date:  2017-08-01       Impact factor: 8.029
  9 in total

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