Masaki Tomita1, Takanori Ayabe2, Eiichi Chosa2, Naohiro Nose2, Kunihide Nakamura3. 1. Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, 889-1692, Japan. mtomita@med.miyazaki-u.ac.jp. 2. Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, 889-1692, Japan. 3. Department of Cardiovascular Surgery, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, 889-1692, Japan.
Abstract
OBJECTIVES: We retrospectively analyzed the prognostic significance of preoperative serum Krebs von den Lungen-6 (KL-6) level in non-small cell lung cancer (NSCLC) patients. METHODS: We enrolled 175 NSCLC patients who underwent curative surgery between 2009 and 2011. We subdivided the patients into 2 groups: with and without interstitial lung disease (ILD). Prognostic significance of serum KL-6 level was examined. RESULTS: The 5-year survival of patients with high serum KL-6 level was poor. Multivariate analysis also revealed the prognostic significance of serum KL-6 level. Serum KL-6 level was also a prognostic factor for patients without ILD. Although the number of patients with ILD was small, in patients with ILD, there was a trend towards an association between serum KL-6 level and patients' prognosis but this did not reach statistical significance. CONCLUSIONS: Serum KL-6 level is a prognostic factor for resected NSCLC patients, especially patients without ILD. There is a possibility that serum KL-6 level is a prognostic marker regardless of the presence of ILD.
OBJECTIVES: We retrospectively analyzed the prognostic significance of preoperative serum Krebs von den Lungen-6 (KL-6) level in non-small cell lung cancer (NSCLC) patients. METHODS: We enrolled 175 NSCLCpatients who underwent curative surgery between 2009 and 2011. We subdivided the patients into 2 groups: with and without interstitial lung disease (ILD). Prognostic significance of serum KL-6 level was examined. RESULTS: The 5-year survival of patients with high serum KL-6 level was poor. Multivariate analysis also revealed the prognostic significance of serum KL-6 level. Serum KL-6 level was also a prognostic factor for patients without ILD. Although the number of patients with ILD was small, in patients with ILD, there was a trend towards an association between serum KL-6 level and patients' prognosis but this did not reach statistical significance. CONCLUSIONS: Serum KL-6 level is a prognostic factor for resected NSCLCpatients, especially patients without ILD. There is a possibility that serum KL-6 level is a prognostic marker regardless of the presence of ILD.
Authors: J Park; D S Kim; T S Shim; C M Lim; Y Koh; S D Lee; W S Kim; W D Kim; J S Lee; K S Song Journal: Eur Respir J Date: 2001-06 Impact factor: 16.671
Authors: Heta Merikallio; Riitta Kaarteenaho; Sara Lindén; Médea Padra; Reza Karimi; Chuan-Xing Li; Elisa Lappi-Blanco; Åsa M Wheelock; Magnus C Sköld Journal: Respir Res Date: 2020-09-18