Anup P Chaudhari, Malleshappa Pavan1, Hemant J Mehta. 1. Division of Nephrology, Department of Medicine, Adichunchanagiri Institute of Medical Sciences, B G Nagara, Karnataka State, India. dr_pavanm@yahoo.co.in.
Abstract
INTRODUCTION: Fluid management in critically ill patients with acute kidney injury (AKI) is controversial. Our study is aimed to evaluate the association between fluid balance and patient outcome in AKI patients admitted to intensive care unit (ICU). MATERIALS AND METHODS: This prospective study was carried out at Lilavati Hospital and Research Centre on 130 critically ill patients with AKI admitted to ICU. Mean daily fluid balance (MDFB) was measured and its correlation with clinical characteristics and outcomes was assessed. RESULTS: During ICU stay, 48.2% patients had a positive and 52.8% had a negative MDFB. In the patients with positive MDFB, mean ICU stay was longer and ventilation requirement, duration of ventilation, inotrope requirement, and duration of inotrope were greater as compared to the group with negative MDFB. A significantly higher mortality rate were observed in the patients with positive MDFB as compared to negative MDFB (43.5% versus 7.4%). CONCLUSIONS: Negative fluid balance was independently associated with a significant reduction in mortality, ICU stay, ventilator requirement, and the need for renal replacement among critically ill patients with AKI.
INTRODUCTION: Fluid management in critically illpatients with acute kidney injury (AKI) is controversial. Our study is aimed to evaluate the association between fluid balance and patient outcome in AKI patients admitted to intensive care unit (ICU). MATERIALS AND METHODS: This prospective study was carried out at Lilavati Hospital and Research Centre on 130 critically illpatients with AKI admitted to ICU. Mean daily fluid balance (MDFB) was measured and its correlation with clinical characteristics and outcomes was assessed. RESULTS: During ICU stay, 48.2% patients had a positive and 52.8% had a negative MDFB. In the patients with positive MDFB, mean ICU stay was longer and ventilation requirement, duration of ventilation, inotrope requirement, and duration of inotrope were greater as compared to the group with negative MDFB. A significantly higher mortality rate were observed in the patients with positive MDFB as compared to negative MDFB (43.5% versus 7.4%). CONCLUSIONS: Negative fluid balance was independently associated with a significant reduction in mortality, ICU stay, ventilator requirement, and the need for renal replacement among critically illpatients with AKI.
Authors: Meiping Wang; Bo Zhu; Li Jiang; Ying Wen; Bin Du; Wen Li; Guangxu Liu; Wei Li; Jing Wen; Yan He; Xiuming Xi Journal: BMJ Open Date: 2020-12-28 Impact factor: 2.692