Literature DB >> 27514463

Laboratory Medicine in the Clinical Decision Support for Treatment of Hypercholesterolemia: Pharmacogenetics of Statins.

Gualberto Ruaño1, Richard Seip2, Andreas Windemuth3, Alan H B Wu4, Paul D Thompson5.   

Abstract

Statin responsiveness is an area of great research interest given the success of the drug class in the treatment of hypercholesterolemia and in primary and secondary prevention of cardiovascular disease. Interrogation of the patient's genome for gene variants will eventually guide anti-hyperlipidemic intervention. In this review, we discuss methodological approaches to discover genetic markers predictive of class-wide and drug-specific statin efficacy and safety. Notable pharmacogenetic findings are summarized from hypothesis-free genome wide and hypothesis-led candidate gene association studies. Physiogenomic models and clinical decision support systems will be required for DNA-guided statin therapy to reach practical use in medicine.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Coenzyme Q(10); Lipid metabolism; Myalgia; Myopathy; PCSK9 inhibitors; Pharmacogenetics; Physiogenomics; Statins

Mesh：

Substances：

Year:  2016        PMID： 27514463      PMCID： PMC4987540          DOI： 10.1016/j.cll.2016.05.010

Source DB:  PubMed          Journal:  Clin Lab Med        ISSN： 0272-2712            Impact factor:   1.935


  72 in total

1.  Statin myopathy: incidence, risk factors, and pathophysiology.

Authors:  Kimberly A Sewright; Priscilla M Clarkson; Paul D Thompson
Journal:  Curr Atheroscler Rep       Date:  2007-11       Impact factor: 5.113

2.  Mechanisms of statin-induced myalgia assessed by physiogenomic associations.

Authors:  Gualberto Ruaño; Andreas Windemuth; Alan H B Wu; John P Kane; Mary J Malloy; Clive R Pullinger; Mohan Kocherla; Kali Bogaard; Bruce R Gordon; Theodore R Holford; Ankur Gupta; Richard L Seip; Paul D Thompson
Journal:  Atherosclerosis       Date:  2011-07-20       Impact factor: 5.162

3.  Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS).

Authors:  Anke-Hilse Maitland-van der Zee; J Wouter Jukema; Aeilko H Zwinderman; D Michael Hallman; Anthonius De Boer; John J P Kastelein; Peter De Knijff
Journal:  Acta Cardiol       Date:  2006-06       Impact factor: 1.718

4.  Increased exposure to statins in patients developing chronic muscle diseases: a 2-year retrospective study.

Authors:  L Sailler; C Pereira; A Bagheri; E Uro-Coste; B Roussel; H Roussel; D Adoue; B Fournie; M Laroche; L Zabraniecki; P Cintas; P Arlet; M Lapeyre-Mestre; J L Montastruc; E Arlet-Suau
Journal:  Ann Rheum Dis       Date:  2007-09-03       Impact factor: 19.103

5.  The SLCO1B1*5 genetic variant is associated with statin-induced side effects.

Authors:  Deepak Voora; Svati H Shah; Ivan Spasojevic; Shazia Ali; Carol R Reed; Benjamin A Salisbury; Geoffrey S Ginsburg
Journal:  J Am Coll Cardiol       Date:  2009-10-20       Impact factor: 24.094

6.  Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study.

Authors:  Joel A Simon; Feng Lin; Stephen B Hulley; Patricia J Blanche; David Waters; Stephen Shiboski; Jerome I Rotter; Deborah A Nickerson; Huiying Yang; Mohammed Saad; Ronald M Krauss
Journal:  Am J Cardiol       Date:  2006-01-27       Impact factor: 2.778

7.  Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.

Authors:  Margareta Forsgren; Anneli Attersand; Staffan Lake; Jacob Grünler; Ewa Swiezewska; Gustav Dallner; Isabel Climent
Journal:  Biochem J       Date:  2004-09-01       Impact factor: 3.857

8.  Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

Authors:  Sekar Kathiresan; Olle Melander; Candace Guiducci; Aarti Surti; Noël P Burtt; Mark J Rieder; Gregory M Cooper; Charlotta Roos; Benjamin F Voight; Aki S Havulinna; Björn Wahlstrand; Thomas Hedner; Dolores Corella; E Shyong Tai; Jose M Ordovas; Göran Berglund; Erkki Vartiainen; Pekka Jousilahti; Bo Hedblad; Marja-Riitta Taskinen; Christopher Newton-Cheh; Veikko Salomaa; Leena Peltonen; Leif Groop; David M Altshuler; Marju Orho-Melander
Journal:  Nat Genet       Date:  2008-01-13       Impact factor: 38.330

9.  Haplotypes of the cholesteryl ester transfer protein gene predict lipid-modifying response to statin therapy.

Authors:  B R Winkelmann; M M Hoffmann; M Nauck; A M Kumar; K Nandabalan; R S Judson; B O Boehm; A R Tall; G Ruaño; W März
Journal:  Pharmacogenomics J       Date:  2003       Impact factor: 3.550

10.  Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

Authors:  Cristen J Willer; Serena Sanna; Anne U Jackson; Angelo Scuteri; Lori L Bonnycastle; Robert Clarke; Simon C Heath; Nicholas J Timpson; Samer S Najjar; Heather M Stringham; James Strait; William L Duren; Andrea Maschio; Fabio Busonero; Antonella Mulas; Giuseppe Albai; Amy J Swift; Mario A Morken; Narisu Narisu; Derrick Bennett; Sarah Parish; Haiqing Shen; Pilar Galan; Pierre Meneton; Serge Hercberg; Diana Zelenika; Wei-Min Chen; Yun Li; Laura J Scott; Paul A Scheet; Jouko Sundvall; Richard M Watanabe; Ramaiah Nagaraja; Shah Ebrahim; Debbie A Lawlor; Yoav Ben-Shlomo; George Davey-Smith; Alan R Shuldiner; Rory Collins; Richard N Bergman; Manuela Uda; Jaakko Tuomilehto; Antonio Cao; Francis S Collins; Edward Lakatta; G Mark Lathrop; Michael Boehnke; David Schlessinger; Karen L Mohlke; Gonçalo R Abecasis
Journal:  Nat Genet       Date:  2008-01-13       Impact factor: 38.330
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  2 in total

1.  Investigation of the Effect of Atorvastatin on Skeletal Muscles in Male Rats and the Involved Mechanisms.

Authors:  K M Hassani
Journal:  Arch Razi Inst       Date:  2022-02-28

2.  Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma.

Authors:  Yikun Peng; Guangchun He; Da Tang; Li Xiong; Yu Wen; Xiongying Miao; Zhangyong Hong; Hui Yao; Chao Chen; Shichao Yan; Lu Lu; Yingke Yang; Qinglong Li; Xiyun Deng
Journal:  J Cancer       Date:  2017-06-03       Impact factor: 4.207
  2 in total

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