Chang Seong Kim1, Eun Hui Bae1, Seong Kwon Ma1, Sue K Park2,3,4, Ju Yeon Lee2, Wookyung Chung5, Kyubeck Lee6, Yeong Hoon Kim7, Kook-Hwan Oh8, Curie Ahn8, Soo Wan Kim9. 1. Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju, 501-757, Korea. 2. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. 3. Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea. 4. Cancer Research Institute, Seoul National University, Seoul, Korea. 5. Department of Internal Medicine, Gil Hospital, Gachon University, Incheon, Korea. 6. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, Korea. 7. Department of Internal Medicine, Pusan Paik Hospital, Inje University, Busan, Korea. 8. Department of Internal Medicine, Seoul National University, Seoul, Korea. 9. Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju, 501-757, Korea. skimw@chonnam.ac.kr.
Abstract
BACKGROUND: High serum adiponectin levels predict all-cause and cardiovascular mortality in chronic kidney disease (CKD). However, the relationship between serum adiponectin concentration and arterial stiffness in CKD is not well established. The aim of this study was to assess this relationship by measuring pulse wave velocity (PWV) in CKD patients. METHODS: Serum adiponectin concentration was measured in 716 CKD patients in the prospective KoreaN cohort study for Outcome in patients With Chronic Kidney Disease. The study group consisted of 415 men and 301 women; mean age was 53.1 years, and baseline estimated glomerular filtration rate (eGFR) was 51 ± 29 ml/min per 1.73 m2. Heart to femoral PWV (hfPWV) and mean brachial to ankle PWV (baPWV) served as indicators of aortic artery stiffness and arterial stiffness, respectively. RESULTS: Increasing quartiles of serum adiponectin levels were associated with women, lower eGFRs and body mass indices, and higher urinary albumin-creatinine ratios. Serum adiponectin concentration also correlated with hfPWV and mean baPWV, even after adjusting for age and sex. It independently associated with hfPWV (B 0.028; 95 % confidence interval, 0.004-0.051; P = 0.020) but not mean baPWV in a multivariable linear regression analysis. In a multivariable logistic regression analysis, it correlated significantly with the highest quartile of hfPWVs but not mean baPWVs. CONCLUSION: The independent and significant correlation of serum adiponectin concentration with hfPWV in CKD patients implicates adiponectin in CKD-associated aortic stiffness.
BACKGROUND: High serum adiponectin levels predict all-cause and cardiovascular mortality in chronic kidney disease (CKD). However, the relationship between serum adiponectin concentration and arterial stiffness in CKD is not well established. The aim of this study was to assess this relationship by measuring pulse wave velocity (PWV) in CKDpatients. METHODS: Serum adiponectin concentration was measured in 716 CKDpatients in the prospective KoreaN cohort study for Outcome in patients With Chronic Kidney Disease. The study group consisted of 415 men and 301 women; mean age was 53.1 years, and baseline estimated glomerular filtration rate (eGFR) was 51 ± 29 ml/min per 1.73 m2. Heart to femoral PWV (hfPWV) and mean brachial to ankle PWV (baPWV) served as indicators of aortic artery stiffness and arterial stiffness, respectively. RESULTS: Increasing quartiles of serum adiponectin levels were associated with women, lower eGFRs and body mass indices, and higher urinary albumin-creatinine ratios. Serum adiponectin concentration also correlated with hfPWV and mean baPWV, even after adjusting for age and sex. It independently associated with hfPWV (B 0.028; 95 % confidence interval, 0.004-0.051; P = 0.020) but not mean baPWV in a multivariable linear regression analysis. In a multivariable logistic regression analysis, it correlated significantly with the highest quartile of hfPWVs but not mean baPWVs. CONCLUSION: The independent and significant correlation of serum adiponectin concentration with hfPWV in CKDpatients implicates adiponectin in CKD-associated aortic stiffness.
Authors: Bruno Pannier; Alain P Guérin; Sylvain J Marchais; Michel E Safar; Gérard M London Journal: Hypertension Date: 2005-03-07 Impact factor: 10.190