Literature DB >> 27513204

The use of brincidofovir for the treatment of mixed dsDNA viral infection.

Jose F Camargo1, Michele I Morris2, Lilian M Abbo2, Jacques Simkins2, Seyyedeh Saneeymehri3, Maritza C Alencar4, Lazaros J Lekakis5, Krishna V Komanduri5.   

Abstract

Double-stranded DNA (dsDNA) viral infections constitute a major complication following solid organ and stem cell transplantation. Few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. Brincidofovir is an oral investigational drug with broad antiviral activity against dsDNA viruses in vitro, but clinical experience is limited. Here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, Epstein-Barr virus and BK polyomavirus after an allogeneic stem cell transplant, and was successfully treated with brincidofovir.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Adenovirus; BK virus; Brincidofovir; CMX001; Cytomegalovirus; Epstein–Barr virus

Mesh：

Substances：

Year:  2016        PMID： 27513204     DOI： 10.1016/j.jcv.2016.07.021

Source DB:  PubMed          Journal:  J Clin Virol        ISSN： 1386-6532            Impact factor:   3.168


  6 in total

1.  Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD.

Authors:  Claire J Detweiler; Sarah B Mueller; Anthony D Sung; Jennifer L Saullo; Vinod K Prasad; Diana M Cardona
Journal:  J Pediatr Hematol Oncol       Date:  2018-08       Impact factor: 1.289

Review 2.  Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation.

Authors:  Ajit P Limaye; Tara M Babu; Michael Boeckh
Journal:  Clin Microbiol Rev       Date:  2020-10-28       Impact factor: 26.132

3.  Anti-adenoviral Artificial MicroRNAs Expressed from AAV9 Vectors Inhibit Human Adenovirus Infection in Immunosuppressed Syrian Hamsters.

Authors:  Katrin Schaar; Anja Geisler; Milena Kraus; Sandra Pinkert; Markian Pryshliak; Jacqueline F Spencer; Ann E Tollefson; Baoling Ying; Jens Kurreck; William S Wold; Robert Klopfleisch; Karoly Toth; Henry Fechner
Journal:  Mol Ther Nucleic Acids       Date:  2017-07-08       Impact factor: 8.886

4.  HAdV-C6 Is a More Relevant Challenge Virus than HAdV-C5 for Testing Antiviral Drugs with the Immunosuppressed Syrian Hamster Model.

Authors:  Karoly Toth; Jacqueline F Spencer; Baoling Ying; Ann E Tollefson; William S M Wold
Journal:  Viruses       Date:  2017-06-13       Impact factor: 5.048

5.  Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection.

Authors:  Romain Vial; Christine Zandotti; Sophie Alain; Alexandre Decourt; Noémie Jourde-Chiche; Raj Purgus; Charleric Bornet; Laurent Daniel; Valérie Moal; Tristan Legris
Journal:  Case Rep Transplant       Date:  2017-02-27

6.  Broad-Spectrum Antiviral Agents: A Crucial Pandemic Tool.

Authors:  Amesh Adalja; Thomas Inglesby
Journal:  Expert Rev Anti Infect Ther       Date:  2019-06-24       Impact factor: 5.091
  6 in total

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