| Literature DB >> 27512900 |
Henry Hampton1, Carolyn Hutcheon1, Naeha Subramanian2.
Abstract
Recognition of peptidoglycan is integral to detection of gram-positive bacterial pathogens. In a recent issue of Cell, Wolf et al. (2016) report that detection of the N-acetylglucosamine component of peptidoglycan by the glycolytic enzyme hexokinase activates the NLRP3 inflammasome, revealing an intriguing interplay between pathogen detection and metabolism.Entities:
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Year: 2016 PMID： 27512900 DOI： 10.1016/j.chom.2016.07.017
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023