BACKGROUND: Cystic fibrosis manifests as a multisystem disease, despite this female fertility is relatively preserved with levels approaching that of the non-cystic fibrosis population. We reviewed pregnancies in cystic fibrosis patients over a 10-year period from a UK adult cystic fibrosis centre by considering maternal and fetal outcomes. METHODS: We conducted a retrospective case-note review of pregnancies during 2003-2013 using respiratory and obstetric records. RESULTS: We observed moderate falls in lung function immediately after delivery, which persisted at 12 months postpartum. We found that a decline in lung function at delivery was a marker for further decline in function during the subsequent postpartum period. We found baseline lung function was predictive of gestational age at delivery. We observed a high incidence of haemoptysis. CONCLUSION: Consistent with current guidance we found pregnancy is feasible and well tolerated in the majority of patients with cystic fibrosis. There was a high incidence of haemoptysis, which warrants further study.
BACKGROUND:Cystic fibrosis manifests as a multisystem disease, despite this female fertility is relatively preserved with levels approaching that of the non-cystic fibrosis population. We reviewed pregnancies in cystic fibrosispatients over a 10-year period from a UK adult cystic fibrosis centre by considering maternal and fetal outcomes. METHODS: We conducted a retrospective case-note review of pregnancies during 2003-2013 using respiratory and obstetric records. RESULTS: We observed moderate falls in lung function immediately after delivery, which persisted at 12 months postpartum. We found that a decline in lung function at delivery was a marker for further decline in function during the subsequent postpartum period. We found baseline lung function was predictive of gestational age at delivery. We observed a high incidence of haemoptysis. CONCLUSION: Consistent with current guidance we found pregnancy is feasible and well tolerated in the majority of patients with cystic fibrosis. There was a high incidence of haemoptysis, which warrants further study.
Entities:
Keywords:
High-risk pregnancy; complications; maternal-fetal medicine; perinatal medicine; thoracic medicine
Authors: Edmund M T Lau; David J Barnes; Carmel Moriarty; Robert Ogle; Ruth Dentice; Jane Civitico; Aurora Avedello; Paul J Torzillo; Peter T Bye Journal: Aust N Z J Obstet Gynaecol Date: 2011-02-07 Impact factor: 2.100
Authors: F P Edenborough; G Borgo; C Knoop; L Lannefors; W E Mackenzie; S Madge; A M Morton; H C Oxley; D J Touw; M Benham; M Johannesson Journal: J Cyst Fibros Date: 2007-11-19 Impact factor: 5.482
Authors: Raksha Jain; Amalia Magaret; Phuong T Vu; Jill M VanDalfsen; Ashley Keller; Alexandra Wilson; Melissa S Putman; Nicole Mayer-Hamblett; Charles R Esther; Jennifer L Taylor-Cousar Journal: BMJ Open Respir Res Date: 2022-06