Literature DB >> 27512446

Missed opportunities: Peripartum hepatic failure in a Chinese immigrant.

Malika Sharma1, Shital Gandhi2.   

Abstract

Hepatitis B surface antigen (HBsAg) positivity presents unique management challenges in pregnancy. We present the case of a 26-year-old HBsAg-positive woman who presented at 35 weeks gestational age with nausea, vomiting, and abdominal pain with markedly elevated liver enzymes. An elevated alpha feto-protein on antenatal screening had been misconstrued as fetal in origin. Magnetic resonance imaging and liver biopsy confirmed hepatocellular carcinoma. She died of fulminant hepatic failure two weeks after emergent delivery. This case highlights the importance of adequate evaluation and management of pregnant patients testing positive for HBsAg on routine antenatal testing.

Entities:  

Keywords:  Gastroenterology; hepatology; high-risk pregnancy; infectious diseases; neoplasm

Year:  2014        PMID: 27512446      PMCID: PMC4934985          DOI: 10.1177/1753495X14546519

Source DB:  PubMed          Journal:  Obstet Med        ISSN: 1753-495X


  8 in total

1.  EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma.

Authors: 
Journal:  J Hepatol       Date:  2012-04       Impact factor: 25.083

2.  Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection.

Authors:  Mustafa Kemal Celen; Duygu Mert; Müzeyyen Ay; Tuba Dal; Safak Kaya; Necmettin Yildirim; Serda Gulsun; Tunga Barcin; Sevgi Kalkanli; Mehmet Sinan Dal; Celal Ayaz
Journal:  World J Gastroenterol       Date:  2013-12-28       Impact factor: 5.742

Review 3.  Breastfeeding of newborns by mothers carrying hepatitis B virus: a meta-analysis and systematic review.

Authors:  Zhongjie Shi; Yuebo Yang; Hao Wang; Lin Ma; Ann Schreiber; Xiaomao Li; Wenjing Sun; Xuan Zhao; Xu Yang; Liran Zhang; Wenli Lu; Jin Teng; Yufang An
Journal:  Arch Pediatr Adolesc Med       Date:  2011-05-02

Review 4.  Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis.

Authors:  Chuanfang Lee; Yan Gong; Jesper Brok; Elizabeth H Boxall; Christian Gluud
Journal:  BMJ       Date:  2006-01-27

5.  Paraneoplastic syndromes in patients with hepatocellular carcinoma in Taiwan.

Authors:  J C Luo; S J Hwang; J C Wu; C P Li; L T Hsiao; C R Lai; J H Chiang; W Y Lui; F Y Chang; S D Lee
Journal:  Cancer       Date:  1999-09-01       Impact factor: 6.860

Review 6.  The spectrum and treatment of gastrointestinal disorders during pregnancy.

Authors:  Jutta Keller; Dorothea Frederking; Peter Layer
Journal:  Nat Clin Pract Gastroenterol Hepatol       Date:  2008-08

7.  Management of hepatitis B in pregnancy: weighing the options.

Authors:  Tram T Tran
Journal:  Cleve Clin J Med       Date:  2009-05       Impact factor: 2.321

8.  Management of hepatocellular carcinoma: an update.

Authors:  Jordi Bruix; Morris Sherman
Journal:  Hepatology       Date:  2011-03       Impact factor: 17.425

  8 in total

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