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Literature DB >> 27511599

Natural Products at Work: Structural Insights into Inhibition of the Bacterial Membrane Protein MraY.

Abstract

Natural(ly) fit: The X-ray crystal structure of the bacterial membrane protein MraY in complex with its natural product inhibitor muraymycin D2 is discussed. MraY catalyzes one of the membrane-associated steps in peptidoglycan biosynthesis and, therefore, represents a promising target for novel antibiotics. Structural insights derived from the protein-inhibitor complex might now pave the way for the development of new antimicrobial drugs.

Entities: Chemical

Keywords: antibiotics; medicinal chemistry; natural products; peptidoglycans; protein crystallography

Mesh：

Substances：

Year: 2016 PMID： 27511599 DOI： 10.1002/anie.201606396

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

8 in total

Review 1. Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance.

Authors: David A Dik; Jed F Fisher; Shahriar Mobashery
Journal: Chem Rev Date: 2018-05-30 Impact factor: 60.622

2. Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics.

Authors: Stefan Koppermann; Zheng Cui; Patrick D Fischer; Xiachang Wang; Jannine Ludwig; Jon S Thorson; Steven G Van Lanen; Christian Ducho
Journal: ChemMedChem Date: 2018-03-23 Impact factor: 3.466

3. Targeting the gram-negative bacteria peptidoglycan synthase MraY as a new approach for monoclonal antibody anti-bacterial activity.

Authors: Jun Cao; Fei Yi; Qiufeng Tian; Guanghui Dang; Wei Si; Siguo Liu; Shenye Yu
Journal: Hum Vaccin Immunother Date: 2017-06-12 Impact factor: 3.452

Review 4. Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics.

Authors: M McErlean; X Liu; Z Cui; B Gust; S G Van Lanen
Journal: Nat Prod Rep Date: 2021-07-21 Impact factor: 15.111

Natural Products at Work: Structural Insights into Inhibition of the Bacterial Membrane Protein MraY.

Review 1. Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance.

2. Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics.

3. Targeting the gram-negative bacteria peptidoglycan synthase MraY as a new approach for monoclonal antibody anti-bacterial activity.

Review 4. Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics.

5. Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins.

6. Analogues of Muraymycin Nucleoside Antibiotics with Epimeric Uridine-Derived Core Structures.

7. Chemical logic of MraY inhibition by antibacterial nucleoside natural products.

8. Muraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside Unit.