Camilo Romero1, Rafael Heredia2, Jocelyn Pineda3, Jonathan A Serrano4, Germán D Mendoza5, Porfirio Trápala6, Alberto M Cordero7. 1. Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Carretera Amecameca-Ayapango Km 2.5, Amecameca de Juárez, CP 56900, Estado de México, México. cromeron@uaemex.mx. 2. Doctorado en Ciencias Agropecuarias y Recursos Naturales, Universidad Autónoma del Estado de México, kilometro 14.5 carretera Toluca-Atlacomulco desviación a Tlachalo, El Cerrillo Piedras Blancas, Toluca, 50200, Estado de México, México. 3. Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Carretera Amecameca-Ayapango Km 2.5, Amecameca de Juárez, CP 56900, Estado de México, México. 4. Licenciatura de Medicina Veterinaria y Zootecnia, Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Carretera Amecameca-Ayapango Km 2.5, Amecameca de Juárez, 56900, Estado de México, México. 5. Universidad Autónoma Metropolitana, Unidad Xochimilco, Calzada del Hueso 1100, Coyoacan, 04960, Mexico DF, México. 6. Clinica Veterinaria Alhaurin, Río Panuco No. 2424, Colonia México, Monterrey, 64740, NL, México. 7. Veterinaria Dermatología Veterinaria Especializada, Argentina No. 690, colonia moderna, Guadalajara, 44190, Jalisco, México.
Abstract
BACKGROUND: There are few licensed options for the treatment of canine sarcoptic mange. OBJECTIVE: To evaluate the efficacy of fluralaner in dogs with sarcoptic mange infestation. ANIMALS: Seventeen dogs with a diagnosis of Sarcoptes scabiei based on positive skin scrapings. METHODS: A single dose of oral fluralaner was administered according to the manufacturer's instructions. Assessments of pruritus and lesions were performed every 7 days for 1 month. RESULTS: By Day 14 post-treatment, skin scrapings from all dogs were negative for mites. At the beginning of the study there was a negative correlation between body weight of the subject and pruritus [Pearson correlation coefficient (PCC) = -0.396, P = 0.007] and a positive correlation between pruritus and lesion severity (PCC 0.755, P = 0.0001). Significant decreases in lesion size and pruritus were observed within the first 14-21 days, respectively, and improvement in these parameters continued until the end of the study at Day 28. CONCLUSION: Fluralaner was effective in eliminating scabies mites within 14 days and significantly resolved the clinical signs associated with sarcoptic mange within 21 days after a single dose.
BACKGROUND: There are few licensed options for the treatment of canine sarcoptic mange. OBJECTIVE: To evaluate the efficacy of fluralaner in dogs with sarcoptic mange infestation. ANIMALS: Seventeen dogs with a diagnosis of Sarcoptes scabiei based on positive skin scrapings. METHODS: A single dose of oral fluralaner was administered according to the manufacturer's instructions. Assessments of pruritus and lesions were performed every 7 days for 1 month. RESULTS: By Day 14 post-treatment, skin scrapings from all dogs were negative for mites. At the beginning of the study there was a negative correlation between body weight of the subject and pruritus [Pearson correlation coefficient (PCC) = -0.396, P = 0.007] and a positive correlation between pruritus and lesion severity (PCC 0.755, P = 0.0001). Significant decreases in lesion size and pruritus were observed within the first 14-21 days, respectively, and improvement in these parameters continued until the end of the study at Day 28. CONCLUSION:Fluralaner was effective in eliminating scabies mites within 14 days and significantly resolved the clinical signs associated with sarcoptic mange within 21 days after a single dose.
Authors: Camilo Romero-Núñez; Linda G Bautista-Gómez; Galia Sheinberg; Alberto Martín-Cordero; Ariadna Flores-Ortega; Rafael Heredia-Cárdenas Journal: Can J Vet Res Date: 2020-07 Impact factor: 1.310
Authors: Vicky Wilkinson; Kotaro Takano; David Nichols; Alynn Martin; Roz Holme; David Phalen; Kate Mounsey; Michael Charleston; Alexandre Kreiss; Ruth Pye; Elizabeth Browne; Christina Næsborg-Nielsen; Shane A Richards; Scott Carver Journal: Parasit Vectors Date: 2021-01-06 Impact factor: 3.876