Literature DB >> 27510730

Stabilisation of metastable polymorphs: the case of paracetamol form III.

Richard Telford1, Colin C Seaton, Alexander Clout, Asma Buanz, Simon Gaisford, Gareth R Williams, Timothy J Prior, Chidera H Okoye, Tasnim Munshi, Ian J Scowen.   

Abstract

The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising 'active' templates of the metastable polymorph.

Entities:  

Year:  2016        PMID： 27510730     DOI： 10.1039/c6cc05006a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Crystallization of Form II Paracetamol with the Assistance of Carboxylic Acids toward Batch and Continuous Processes.

Authors:  Kuan-Lin Yeh; Hung-Lin Lee; Tu Lee
Journal:  Pharmaceutics       Date:  2022-05-20       Impact factor: 6.525

Review 2.  Periodic DFT Calculations-Review of Applications in the Pharmaceutical Sciences.

Authors:  Anna Helena Mazurek; Łukasz Szeleszczuk; Dariusz Maciej Pisklak
Journal:  Pharmaceutics       Date:  2020-05-01       Impact factor: 6.321

3.  Polymorphic Phase Transitions in Carbamazepine and 10,11-Dihydrocarbamazepine.

Authors:  Alexander E Clout; Asma B M Buanz; Simon Gaisford; Gareth R Williams
Journal:  Chemistry       Date:  2018-08-20       Impact factor: 5.236

4.  Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives.

Authors:  Tomislav Portada; Davor Margetić; Vjekoslav Štrukil
Journal:  Molecules       Date:  2018-11-30       Impact factor: 4.411

5.  Stabilisation and Growth of Metastable Form II of Fluconazole in Amorphous Solid Dispersions.

Authors:  Maciej Nowak; Maciej Gajda; Przemysław Baranowski; Patrycja Szymczyk; Bożena Karolewicz; Karol P Nartowski
Journal:  Pharmaceutics       Date:  2019-12-20       Impact factor: 6.321

6.  Mechanistic In Situ and Ex Situ Studies of Phase Transformations in Molecular Co-Crystals.

Authors:  Alexander E Clout; Asma B M Buanz; Yuying Pang; Wing-Mei Tsui; Dongpeng Yan; Gary Parkinson; Timothy J Prior; Dejan-Krešimir Bučar; Simon Gaisford; Gareth R Williams
Journal:  Chemistry       Date:  2020-10-07       Impact factor: 5.236

7.  Drug-Polymer Interactions in Acetaminophen/Hydroxypropylmethylcellulose Acetyl Succinate Amorphous Solid Dispersions Revealed by Multidimensional Multinuclear Solid-State NMR Spectroscopy.

Authors:  Andrea Pugliese; Michael Toresco; Daniel McNamara; Dinu Iuga; Anuji Abraham; Michael Tobyn; Lucy E Hawarden; Frédéric Blanc
Journal:  Mol Pharm       Date:  2021-08-10       Impact factor: 4.939

8.  Monitoring Polymorphic Phase Transitions in Flufenamic Acid Amorphous Solid Dispersions Using Hyphenated X-ray Diffraction-Differential Scanning Calorimetry.

Authors:  Yuying Pang; Asma Buanz; Simon Gaisford; Oxana V Magdysyuk; Gareth R Williams
Journal:  Mol Pharm       Date:  2022-03-29       Impact factor: 5.364

9.  Stabilization of Metastable Indomethacin α in Cellulose Nanocrystal Aerogel Scaffolds.

Authors:  Manali Banerjee; Blair Brettmann
Journal:  Pharmaceutics       Date:  2021-03-24       Impact factor: 6.321
  9 in total

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