Laura de Ramon, Marta Jarque, Elia Ripoll, Oriol Bestard, Josep M Grinyo, Juan Torras1. 1. Experimental Nephrology, Departament de Ciències Clíniques, Universitat de Barcelona, Institut d'investigació biomedica de Bellvitge (IDIBELL), Hospitalet Llobregat, Barcelona, Spain. jtorras@bellvitgehospital.cat.
Abstract
BACKGROUND: Ischemia reperfusion injury is an important pathophysiological process in many fields such as transplantation, stroke, atherosclerosis, trauma and myocardial infarction. Recent advances in gene silencing may help to reduce ischemic effects, targeting molecules related to this pathological process. METHODS AND RESULTS: Here, we review the different silencing approaches in ischemic injury, highlighting the role of co-stimulatory molecules in renal transplantation. CONCLUSION: Gene silencing appears as a new strategy to prevent the inflammation and injury associated with ischemia.
BACKGROUND:Ischemia reperfusion injury is an important pathophysiological process in many fields such as transplantation, stroke, atherosclerosis, trauma and myocardial infarction. Recent advances in gene silencing may help to reduce ischemic effects, targeting molecules related to this pathological process. METHODS AND RESULTS: Here, we review the different silencing approaches in ischemic injury, highlighting the role of co-stimulatory molecules in renal transplantation. CONCLUSION: Gene silencing appears as a new strategy to prevent the inflammation and injury associated with ischemia.
Authors: Alonso Narváez; Roser Guiteras; Anna Sola; Anna Manonelles; Juan Morote; Juan Torras; Josep M Grinyó; Josep M Cruzado Journal: PLoS One Date: 2019-04-12 Impact factor: 3.240