| Literature DB >> 27509407 |
J L Bueno1, M Ynigo2, C de Miguel1, R M Gonzalo-Daganzo1, A Richart3, C Vilches4, C Regidor1, J A García-Marco1, E Flores-Ballester3, J R Cabrera1.
Abstract
Recent research suggests that growth differentiation factor 11 (GDF11) could reverse age-related diseases and that its blood concentration decreases with age. This poses plasma from young donors as a therapeutic GDF11 source to treat age-related diseases. In addition, the tissue source of circulating GDF11 remains unknown. We analysed GDF11 levels in paired samples of serum, plasma and platelet lysate (PL) from 23 volunteers. Plasma and PL were collected by plateletpheresis. Here, we show that GDF11 is highly concentrated in platelets and that the circulating levels reported in previous studies could be biased as a result of serum sample manipulation.Entities:
Keywords: Platelet Rich Plasma (PRP); apheresis; cytokine; plasma; regenerative medicine ageing
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Year: 2016 PMID： 27509407 DOI： 10.1111/vox.12438
Source DB: PubMed Journal: Vox Sang ISSN： 0042-9007 Impact factor: 2.144