Literature DB >> 27508869

Sex and Gender: Critical Variables in Pre-Clinical and Clinical Medical Research.

Eugenia Morselli1, Aaron P Frank2, Roberta S Santos3, Luciana A Fátima4, Biff F Palmer5, Deborah J Clegg6.   

Abstract

In this Essay, we discuss the critical need to incorporate sex and gender in pre-clinical and clinical research to enhance our understanding of the mechanisms by which metabolic processes differ by sex and gender. This knowledge will allow for development of personalized medicine which will optimize therapies specific for individuals.
Copyright © 2016 Elsevier Inc. All rights reserved.

Keywords:  cardiovascular diseases; chromosome; estrogens; gender; obesity; sex; testosterone; type 2 diabetes

Mesh：

Substances：

Year:  2016        PMID： 27508869     DOI： 10.1016/j.cmet.2016.07.017

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  17 in total

Review 1.  The effects of oestrogens and their receptors on cardiometabolic health.

Authors:  Eugenia Morselli; Roberta S Santos; Alfredo Criollo; Michael D Nelson; Biff F Palmer; Deborah J Clegg
Journal:  Nat Rev Endocrinol       Date:  2017-03-17       Impact factor: 43.330

2.  Sex differences in murine myocutaneous flap revascularization.

Authors:  Jacquelyn S Brandenburg; Ross M Clark; Brittany Coffman; Geetanjali Sharma; Helen J Hathaway; Eric R Prossnitz; Thomas R Howdieshell
Journal:  Wound Repair Regen       Date:  2020-05-19       Impact factor: 3.617

3.  Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.

Authors:  João Paulo Camporez; Kun Lyu; Emily L Goldberg; Dongyan Zhang; Gary W Cline; Michael J Jurczak; Vishwa Deep Dixit; Kitt Falk Petersen; Gerald I Shulman
Journal:  J Physiol       Date:  2019-07-04       Impact factor: 5.182

Review 4.  The Differences by Sex and Gender in the Relationship Between Urban Greenness and Cardiometabolic Health: A Systematic Review.

Authors:  Marta-Beatriz Fernández Núñez; Lia Campos Suzman; Roser Maneja; Albert Bach; Oriol Marquet; Isabelle Anguelovski; Pablo Knobel
Journal:  J Urban Health       Date:  2022-09-30       Impact factor: 5.801

5.  Differential effects of age and sex on insulin sensitivity and body composition in adolescent offspring of women with type 1 diabetes: results from the EPICOM study.

Authors:  Zuzana Lohse; Sine Knorr; Birgitte Bytoft; Tine D Clausen; Rikke B Jensen; Peter Oturai; Henning Beck-Nielsen; Claus H Gravholt; Peter Damm; Kurt Højlund; Dorte M Jensen
Journal:  Diabetologia       Date:  2017-10-03       Impact factor: 10.122

6.  Maternal metabolic adaptations are necessary for normal offspring growth and brain development.

Authors:  Angela M Ramos-Lobo; Isadora C Furigo; Pryscila D S Teixeira; Thais T Zampieri; Frederick Wasinski; Daniella C Buonfiglio; Jose Donato
Journal:  Physiol Rep       Date:  2018-03

7.  Large-scale in silico identification of drugs exerting sex-specific effects in the heart.

Authors:  Changting Cui; Chuanbo Huang; Kejia Liu; Guoheng Xu; Jichun Yang; Yong Zhou; Yingmei Feng; Georgios Kararigas; Bin Geng; Qinghua Cui
Journal:  J Transl Med       Date:  2018-08-29       Impact factor: 5.531

8.  An integrated view of sex differences in metabolic physiology and disease.

Authors:  Deborah J Clegg; Franck Mauvais-Jarvis
Journal:  Mol Metab       Date:  2018-06-21       Impact factor: 7.422

9.  Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress.

Authors:  Ismael González-García; Cristina Contreras; Ánxela Estévez-Salguero; Francisco Ruíz-Pino; Benoit Colsh; Iván Pensado; Laura Liñares-Pose; Eva Rial-Pensado; Pablo B Martínez de Morentin; Johan Fernø; Carlos Diéguez; Rubén Nogueiras; Hervé Le Stunff; Christophe Magnan; Manuel Tena-Sempere; Miguel López
Journal:  Cell Rep       Date:  2018-10-09       Impact factor: 9.423

Review 10.  The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts.

Authors:  Omer Faruk Kirlangic; Didem Yilmaz-Oral; Ecem Kaya-Sezginer; Gamze Toktanis; Aybuke Suveyda Tezgelen; Ekrem Sen; Armagan Khanam; Cetin Volkan Oztekin; Serap Gur
Journal:  Sex Med       Date:  2020-03-20       Impact factor: 2.491
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