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Literature DB >> 27508867

When Hexokinase Gets that NAG-ing Feeling….

David O'Sullivan¹, Beth Kelly², Erika L Pearce³.

Abstract

Immune cell recognition of bacterial products usually occurs via specific pattern recognition receptors, but new research recently published in Cell by Wolf et al. (2016) demonstrates that the glycolytic enzyme hexokinase can act as an innate immune sensor by binding to bacterial derived N-acetylglucosamine (NAG).

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2016 PMID： 27508867 PMCID： PMC5572107 DOI： 10.1016/j.cmet.2016.07.021

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

10 in total

1. Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection.

Authors: Takeshi Ichinohe; Tatsuya Yamazaki; Takumi Koshiba; Yusuke Yanagi
Journal: Proc Natl Acad Sci U S A Date: 2013-10-14 Impact factor: 11.205

2. K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.

Authors: Raúl Muñoz-Planillo; Peter Kuffa; Giovanny Martínez-Colón; Brenna L Smith; Thekkelnaycke M Rajendiran; Gabriel Núñez
Journal: Immunity Date: 2013-06-27 Impact factor: 31.745

Review 3. Mechanism of NLRP3 inflammasome activation.

Authors: Fayyaz S Sutterwala; Stefanie Haasken; Suzanne L Cassel
Journal: Ann N Y Acad Sci Date: 2014-05-19 Impact factor: 5.691

4. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.

Authors: Bart Everts; Eyal Amiel; Stanley Ching-Cheng Huang; Amber M Smith; Chih-Hao Chang; Wing Y Lam; Veronika Redmann; Tori C Freitas; Julianna Blagih; Gerritje J W van der Windt; Maxim N Artyomov; Russell G Jones; Erika L Pearce; Edward J Pearce
Journal: Nat Immunol Date: 2014-02-23 Impact factor: 25.606

5. A role for mitochondria in NLRP3 inflammasome activation.

Authors: Rongbin Zhou; Amir S Yazdi; Philippe Menu; Jürg Tschopp
Journal: Nature Date: 2010-12-01 Impact factor: 49.962

6. Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

Authors: G M Tannahill; A M Curtis; J Adamik; E M Palsson-McDermott; A F McGettrick; G Goel; C Frezza; N J Bernard; B Kelly; N H Foley; L Zheng; A Gardet; Z Tong; S S Jany; S C Corr; M Haneklaus; B E Caffrey; K Pierce; S Walmsley; F C Beasley; E Cummins; V Nizet; M Whyte; C T Taylor; H Lin; S L Masters; E Gottlieb; V P Kelly; C Clish; P E Auron; R J Xavier; L A J O'Neill
Journal: Nature Date: 2013-03-24 Impact factor: 49.962

1 in total

Review 1. Biochemistry of proinflammatory macrophage activation.

Authors: Yannic Nonnenmacher; Karsten Hiller
Journal: Cell Mol Life Sci Date: 2018-03-03 Impact factor: 9.261

1 in total

When Hexokinase Gets that NAG-ing Feeling….

1. Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection.

2. K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.

Review 3. Mechanism of NLRP3 inflammasome activation.

4. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.

5. A role for mitochondria in NLRP3 inflammasome activation.

6. Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

7. Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan.

8. Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation.

9. Defective mitochondrial fission augments NLRP3 inflammasome activation.

Review 10. Immunometabolism governs dendritic cell and macrophage function.

Review 1. Biochemistry of proinflammatory macrophage activation.