Sanjay Mehendale1, S Venkatasubramanian, C P Girish Kumar, Gagandeep Kang, M D Gupte, Rashmi Arora. 1. National Institute of Epidemiology, Chennai; *Christian Medical College, Vellore; and Indian Council of Medical Research, New Delhi; India. Correspondence to: Dr. Sanjay Mehendale, Director, National Institute of Epidemiology, Indian Council of Medical Research, II Main Road, TNHB, Ayapakkam, Chennai 600077, India. sanjaymehendale@icmr.org.in.
Abstract
OBJECTIVE: To extend a nation-wide rotavirus surveillance network in India, and to generate geographically representative data on rotaviral disease burden and prevalent strains. DESIGN: Hospital-based surveillance. SETTING: A comprehensive multicenter, multi-state hospital based surveillance network was established in a phased manner involving 28 hospital sites across 17 states and two union territories in India. PATIENTS: Cases of acute diarrhea among children below 5 years of age admitted in the participating hospitals. RESULTS: During the 28 month study period between September 2012 and December 2014, 11898 children were enrolled and stool samples from 10207 children admitted with acute diarrhea were tested; 39.6% were positive for rotavirus. Highest positivity was seen in Tanda (60.4%) and Bhubaneswar (60.4%) followed by Midnapore (59.5%). Rotavirus infection was seen more among children aged below 2 years with highest (46.7%) positivity in the age group of 12-23 months. Cooler months of September to February accounted for most of the rotavirus associated gastroenteritis, with highest prevalence seen during December to February (56.4%). 64% of rotaviru -infected children had severe to very severe disease. G1 P[8] was the predominant rotavirus strain (62.7%) during the surveillance period. CONCLUSION: The surveillance data highlights the high rotaviral disease burden in India. The network will continue to be a platform for monitoring the impact of the vaccine.
OBJECTIVE: To extend a nation-wide rotavirus surveillance network in India, and to generate geographically representative data on rotaviral disease burden and prevalent strains. DESIGN: Hospital-based surveillance. SETTING: A comprehensive multicenter, multi-state hospital based surveillance network was established in a phased manner involving 28 hospital sites across 17 states and two union territories in India. PATIENTS: Cases of acute diarrhea among children below 5 years of age admitted in the participating hospitals. RESULTS: During the 28 month study period between September 2012 and December 2014, 11898 children were enrolled and stool samples from 10207 children admitted with acute diarrhea were tested; 39.6% were positive for rotavirus. Highest positivity was seen in Tanda (60.4%) and Bhubaneswar (60.4%) followed by Midnapore (59.5%). Rotavirus infection was seen more among children aged below 2 years with highest (46.7%) positivity in the age group of 12-23 months. Cooler months of September to February accounted for most of the rotavirus associated gastroenteritis, with highest prevalence seen during December to February (56.4%). 64% of rotaviru -infectedchildren had severe to very severe disease. G1 P[8] was the predominant rotavirus strain (62.7%) during the surveillance period. CONCLUSION: The surveillance data highlights the high rotaviral disease burden in India. The network will continue to be a platform for monitoring the impact of the vaccine.
Authors: Daniel S Farrar; Shally Awasthi; Shaza A Fadel; Rajesh Kumar; Anju Sinha; Sze Hang Fu; Brian Wahl; Shaun K Morris; Prabhat Jha Journal: Elife Date: 2019-08-27 Impact factor: 8.140
Authors: Jillian Murray; S Yati Soenarto; Nenny S Mulyani; Pushpa S Wijesinghe; Evans M Mpabalwani; Julia C Simwaka; Belem Matapo; Jason M Mwenda; Gayane Sahakyan; Svetlana Grigoryan; Artavazd Vanyan; Sergey Khactatryan; Jennifer Sanwogou; Lúcia Helena de Oliveira; Gloria Rey-Benito; Gagandeep Kang; Fatima Serhan; Jacqueline E Tate; Negar Aliabadi; Adam L Cohen Journal: Emerg Infect Dis Date: 2019-12 Impact factor: 6.883