Literature DB >> 27508110

Omental transplantation in a patient with mild ALS.

Hernando Rafael1.   

Abstract

To demonstrate that amyotrophic lateral sclerosis (ALS) is not a neurodegenerative disease. The patient, a 33-year-old man began with symptoms of the bulbar form of ALS, characterized by burning pain in both feet during two months and then, he presented right crural monoparesis, fasciculations, slight dysarthria and he walked with help of orthopedic devices. A preoperative MRI scans showed atherosclerosis at the V4 segment of the left vertebral artery. On May 2012, he received an omental transplantation on the anterior, left lateral and posterior surface of the medulla oblongata. About 48 hours after surgery, the dysarthria disappeared and the voluntary movement of the right foot improved. Three days later, he walked without aid of orthopedic device. At present, four years after operation he present complete reversal of symptoms. In conclusión, this patient confirms that bulbar ALS is of ischemic origin and therefore, mild ALS can be cured.

Entities:  

Keywords:  Amyotrophic lateral sclerosis; bulbar ischemia; mild ALS; omental transplantation; vertebral atherosclerosis

Year:  2016        PMID: 27508110      PMCID: PMC4965616     

Source DB:  PubMed          Journal:  Am J Neurodegener Dis        ISSN: 2165-591X


  12 in total

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Review 3.  Omental transplantation for neurodegenerative diseases.

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Journal:  Am J Neurodegener Dis       Date:  2014-09-06

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Authors:  Valerio Russo; Claire Yu; Paul Belliveau; Andrew Hamilton; Lauren E Flynn
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9.  Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up.

Authors:  H Deda; M C Inci; A E Kürekçi; A Sav; K Kayihan; E Ozgün; G E Ustünsoy; S Kocabay
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10.  Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: phase 1 trial outcomes.

Authors:  Eva L Feldman; Nicholas M Boulis; Junguk Hur; Karl Johe; Seward B Rutkove; Thais Federici; Meraida Polak; Jane Bordeau; Stacey A Sakowski; Jonathan D Glass
Journal:  Ann Neurol       Date:  2014-03-07       Impact factor: 10.422

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  1 in total

1.  Etiology and treatment of amyotrophic lateral sclerosis.

Authors:  Hernando Rafael; Juan Oscar David; Antonio Santiago Vilca
Journal:  Am J Neurodegener Dis       Date:  2017-04-15
  1 in total

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