Marie Villain1, Charlotte Cosin2, Bertrand Glize1, Sylvie Berthoz1, Joel Swendsen1, Igor Sibon1, Willy Mayo1. 1. From the Université de Bordeaux, INCIA, CNRS UMR5287, Talence, France (M.V., C.C., J.S., I.S., W.M.); Ecole Pratique des Hautes Etudes, Paris, France (M.V., C.C., J.S.); CHU Bordeaux, Pôle de Neurosciences Cliniques, Hôpital Pellegrin, Bordeaux, France (B.G., I.S.); and CESP, Université Paris Sud, Institut Mutualiste Montsouris, Paris, France (S.B.). 2. From the Université de Bordeaux, INCIA, CNRS UMR5287, Talence, France (M.V., C.C., J.S., I.S., W.M.); Ecole Pratique des Hautes Etudes, Paris, France (M.V., C.C., J.S.); CHU Bordeaux, Pôle de Neurosciences Cliniques, Hôpital Pellegrin, Bordeaux, France (B.G., I.S.); and CESP, Université Paris Sud, Institut Mutualiste Montsouris, Paris, France (S.B.). charlotte.cosin@ephe.sorbonne.fr.
Abstract
BACKGROUND AND PURPOSE: Poststroke depression (PSD) is a frequent complication of stroke with detrimental consequences in terms of quality of life and functional outcomes. In individuals with major depression, several studies have demonstrated an alteration of affective prosody. The aim of this study is to identify prosodic markers that may be predictive of PSD. METHODS: Patient voices were recorded at baseline and 3 months after stroke. We extracted prosodic parameters, including fundamental frequency, percentage of voice breaks, and shimmer. Depression and anxiety symptoms were assessed 3 months later. RESULTS: Among the 49 patients included in the study, 22.5% developed PSD 3 months after stroke. A significant decrease was observed concerning the fundamental frequency among patients who developed PSD. Discriminant analysis demonstrated that initial voice breaks coupled with shimmer are strongly predictive of subsequent PSD. CONCLUSIONS: Early alterations of affective prosody are associated with a higher risk of PSD 3 months after a stroke. This new physiological approach overcomes traditional barriers associated with clinical instruments and contributes to the prediction of this disorder.
BACKGROUND AND PURPOSE:Poststroke depression (PSD) is a frequent complication of stroke with detrimental consequences in terms of quality of life and functional outcomes. In individuals with major depression, several studies have demonstrated an alteration of affective prosody. The aim of this study is to identify prosodic markers that may be predictive of PSD. METHODS:Patient voices were recorded at baseline and 3 months after stroke. We extracted prosodic parameters, including fundamental frequency, percentage of voice breaks, and shimmer. Depression and anxiety symptoms were assessed 3 months later. RESULTS: Among the 49 patients included in the study, 22.5% developed PSD 3 months after stroke. A significant decrease was observed concerning the fundamental frequency among patients who developed PSD. Discriminant analysis demonstrated that initial voice breaks coupled with shimmer are strongly predictive of subsequent PSD. CONCLUSIONS: Early alterations of affective prosody are associated with a higher risk of PSD 3 months after a stroke. This new physiological approach overcomes traditional barriers associated with clinical instruments and contributes to the prediction of this disorder.