Literature DB >> 27506881

The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.

J Wang1.   

Abstract

Plasma membrane monoamine transporter (PMAT) is a new polyspecific organic cation transporter that transports a variety of biogenic amines and xenobiotic cations. Highly expressed in the brain, PMAT represents a major uptake2 transporter for monoamine neurotransmitters. At the blood-cerebrospinal fluid (CSF) barrier, PMAT is the principal organic cation transporter for removing neurotoxins and drugs from the CSF. Here I summarize our latest understanding of PMAT and its roles in monoamine uptake and xenobiotic disposition.
© 2016 American Society for Clinical Pharmacology and Therapeutics.

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Year:  2016        PMID： 27506881      PMCID： PMC5305120          DOI： 10.1002/cpt.442

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  71 in total

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Authors:  R A B van Waterschoot; R ter Heine; E Wagenaar; C M M van der Kruijssen; R W Rooswinkel; A D R Huitema; J H Beijnen; A H Schinkel
Journal:  Br J Pharmacol       Date:  2010-07       Impact factor: 8.739

Review 2.  Catecholamine/Serotonin interactions: systems thinking for brain function and disease.

Authors:  Julie G Hensler; Francesc Artigas; Analía Bortolozzi; Lynette C Daws; Philippe De Deurwaerdère; Léa Milan; Sylvia Navailles; Wouter Koek
Journal:  Adv Pharmacol       Date:  2013

3.  Organic cation transport in rat choroid plexus cells studied by fluorescence microscopy.

Authors:  D S Miller; A R Villalobos; J B Pritchard
Journal:  Am J Physiol       Date:  1999-04

4.  Expression and immunolocalization of the plasma membrane monoamine transporter in the brain.

Authors:  A Dahlin; L Xia; W Kong; R Hevner; J Wang
Journal:  Neuroscience       Date:  2007-04-03       Impact factor: 3.590

Review 5.  Isoquinoline neurotoxins in the brain and Parkinson's disease.

Authors:  T Nagatsu
Journal:  Neurosci Res       Date:  1997-10       Impact factor: 3.304

6.  rOCT2 is a basolateral potential-driven carrier, not an organic cation/proton exchanger.

Authors:  D H Sweet; J B Pritchard
Journal:  Am J Physiol       Date:  1999-12

7.  Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice.

Authors:  Nicole L Baganz; Rebecca E Horton; Alfredo S Calderon; W Anthony Owens; Jaclyn L Munn; Lora T Watts; Nina Koldzic-Zivanovic; Nathaniel A Jeske; Wouter Koek; Glenn M Toney; Lynette C Daws
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-24       Impact factor: 11.205

8.  Differential Uptake Mechanisms of Fluorescent Substrates into Stem-Cell-Derived Serotonergic Neurons.

Authors:  Friederike Matthaeus; Patrick Schloss; Thorsten Lau
Journal:  ACS Chem Neurosci       Date:  2015-10-30       Impact factor: 4.418

9.  The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway.

Authors:  Mei Cui; Radha Aras; Whitney V Christian; Phillip M Rappold; Mamata Hatwar; Joseph Panza; Vernice Jackson-Lewis; Jonathan A Javitch; Nazzareno Ballatori; Serge Przedborski; Kim Tieu
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-29       Impact factor: 11.205

10.  Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene.

Authors:  Dea Adamsen; Vincent Ramaekers; Horace Tb Ho; Corinne Britschgi; Véronique Rüfenacht; David Meili; Elise Bobrowski; Paule Philippe; Caroline Nava; Lionel Van Maldergem; Rémy Bruggmann; Susanne Walitza; Joanne Wang; Edna Grünblatt; Beat Thöny
Journal:  Mol Autism       Date:  2014-08-13       Impact factor: 7.509
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  15 in total

Review 1.  Choroid Plexus and Drug Removal Mechanisms.

Authors:  Austin Sun; Joanne Wang
Journal:  AAPS J       Date:  2021-05-03       Impact factor: 4.009

2.  Live Tissue Imaging Reveals Distinct Transcellular Pathways for Organic Cations and Anions at the Blood-Cerebrospinal Fluid Barrier.

Authors:  Tao Hu; Weibin Zha; Austin Sun; Joanne Wang
Journal:  Mol Pharmacol       Date:  2022-02-22       Impact factor: 4.436

3.  Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland.

Authors:  Bo Hyun Lee; Bertil Hille; Duk-Su Koh
Journal:  Proc Natl Acad Sci U S A       Date:  2021-10-26       Impact factor: 11.205

4.  Clinical Applications and the Roles of Transporters in Disposition, Tumor Targeting, and Tissue Toxicity of meta-Iodobenzylguanidine (mIBG).

Authors:  Antonio J Lopez Quiñones; Leticia Salvador Vieira; Joanne Wang
Journal:  Drug Metab Dispos       Date:  2022-02-22       Impact factor: 3.579

Review 5.  The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances.

Authors:  Julian Maier; Marco Niello; Deborah Rudin; Lynette C Daws; Harald H Sitte
Journal:  Handb Exp Pharmacol       Date:  2021

Review 6.  Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits.

Authors:  Shreyas Bhat; Ali El-Kasaby; Michael Freissmuth; Sonja Sucic
Journal:  Pharmacol Ther       Date:  2020-12-10       Impact factor: 12.310

7.  Targeting Serotonin Transporters in the Treatment of Juvenile and Adolescent Depression.

Authors:  Melodi A Bowman; Lynette C Daws
Journal:  Front Neurosci       Date:  2019-02-27       Impact factor: 4.677

8.  Bidirectional transport of 2-chloroadenosine by equilibrative nucleoside transporter 4 (hENT4): Evidence for allosteric kinetics at acidic pH.

Authors:  David Tandio; Gonzalo Vilas; James R Hammond
Journal:  Sci Rep       Date:  2019-09-19       Impact factor: 4.379

9.  Organic Cation Transporters in Psychiatric Disorders.

Authors:  Lynette C Daws
Journal:  Handb Exp Pharmacol       Date:  2021

Review 10.  Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism.

Authors:  Nikolaos Tsesmetzis; Cynthia B J Paulin; Sean G Rudd; Nikolas Herold
Journal:  Cancers (Basel)       Date:  2018-07-23       Impact factor: 6.639
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